Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation disease BEFREE The gene encoding for transcription factor 7-like 2 (<i>TCF7L2</i>) is the strongest type 2 diabetes mellitus (T2DM) candidate gene discovered to date. 29317436 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker disease BEFREE A matched case-control study was performed to investigate the association between common variants in four genes (CDKAL1, GLIS3, GRK5, and TCF7L2) and symptoms of T2DM. 26919830 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation disease GWASCAT Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes. 29358691 2018
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.700 GeneticVariation disease GWASCAT GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12. 29471430 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation disease BEFREE Some of the variants in TCF7L2 and CDKN2A/2B associated with T2DM are associated with EOT2DM as well. 27488727 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation disease GWASCAT Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation disease GWASCAT Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility. 27189021 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker disease CTD_human Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation disease BEFREE This study aimed to study the effect of variations in TCF7L2 on therapeutic response to sulfonylureas in Type 2 diabetes mellitus patients. 27639123 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation disease BEFREE KCNJ11, ABCC8 and TCF7L2 polymorphisms and the response to sulfonylurea treatment in patients with type 2 diabetes: a bioinformatics assessment. 28587604 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation disease GWASCAT Genetics of Type 2 Diabetes in U.S. Hispanic/Latino Individuals: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). 28254843 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation disease BEFREE A novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women. 28253288 2017
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.700 GeneticVariation disease GWASCAT Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. 26965516 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation disease BEFREE Prevalence of the rs7903146C>T polymorphism in TCF7L2 gene for prediction of type 2 diabetes risk among Iranians of different ethnicities. 26604685 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation disease BEFREE Association with GDM was found for two of the most frequently replicated T2D loci: a TCF7L2 haplotype (CTTC: rs7901695, rs4506565, rs7903146, rs12243326; P=2.16 x 10(-06); OR=2.95) and a KCNQ1 haplotype (TTT: rs2237892, rs163184, rs2237897; P=1.98 x 10(-05); OR=0.55). 25973943 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation disease BEFREE The rs7903146-T allele in the transcription factor 7-like 2 (TCF7L2) gene has been associated with impaired pancreatic insulin secretion, enhanced liver glucose production, and an increased risk of type 2 diabetes. 26914832 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation disease BEFREE TCF7L2 rs7903146 polymorphism and diabetic nephropathy association is not independent of type 2 diabetes--a study in a south Indian population and meta-analysis. 25185853 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation disease BEFREE Association between transcription factor 7-like 2 rs7903146 polymorphism and diabetic retinopathy in type 2 diabetes mellitus: A meta-analysis. 26316572 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation disease BEFREE Association of the Genetic Polymorphisms in Transcription Factor 7-Like 2 and Peroxisome Proliferator-Activated Receptors- γ 2 with Type 2 Diabetes Mellitus and is Interaction with Obesity Status in Emirati Population. 26273662 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker disease BEFREE We selected 32 genetic variants from 11 genes (CDC123, CDKAL1, CDKN2B, FTO, GLIS3, HHEX, IGF2BP2, KCNJ11, KCNQ1, SLC30A8, and TCF7L2) and intergenic regions based on results of recent genome-wide association studies (GWAS) in T2DM. 26499758 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation disease BEFREE Type 2 diabetes mellitus susceptibility gene TCF7L2 is strongly associated with hyperglycemia in the Saudi Arabia Population of the eastern province of Saudi Arabia. 26367734 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker disease BEFREE The aim of this study was to investigate the role of common variants in the genes SLC30A8, KCNQ1, and TCF7L2 in the association between birth weight and increased risk of type 2 diabetes in Han Chinese. 26109524 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation disease BEFREE Association of TCF7L2 Genetic Polymorphisms with Type 2 Diabetes Mellitus in the Uygur Population of China. 26393635 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation disease BEFREE The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis. 26576435 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker disease BEFREE Both MDR and multiplicative logistic regression revealed potential gene-gene interactions among LRP5, TCF7L2, and GCG associated with T2DM. 26083111 2016