Acute leukemia
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
By screening for immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangements in bone marrow samples aspirated at different time points during the course of disease from 43 patients with acute leukaemia we have analysed the extent of clonal evolution after autologous bone marrow transplantation (ABMT) and addressed the issue of whether the Southern Blot method has the power to reveal clonal proliferations representing minimal residual disease (MRD) in the autologous bone marrow grafts.
|
8698127 |
1996 |
Acute leukemia
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Five cases of acute leukemia (AL) with the t(4;11) translocation were investigated for the immunoglobulin heavy chain, kappa, lambda, TCR beta and TCR gamma gene rearrangements.
|
1375695 |
1992 |
Acute leukemia
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In order to clarify whether HTLV-I plays a role as a virus-encoded superantigen in the neoplastic process, we examined the TCR V beta families in the peripheral blood at four different clinical stages: carrier, smoldering leukemia, chronic leukemia, and acute leukemia.
|
8638605 |
1996 |
Acute leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
In this study, we analysed 49 children with acute leukaemia (29 B-precursor acute lymphoblastic leukaemia (ALL), 5 relapsed cALL, 6 T-ALL, 7 acute non-lymphocytic (ANLL) and 2 mixed lineage leukaemias), for the presence of different immune system gene rearrangements (Ig JH, C kappa, C lambda, TCR J gamma, C beta, J delta and J alpha) by Southern blot hybridisation.
|
7786608 |
1995 |
Acute leukemia
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Inappropriately rearranged IgH or TCR genes are usually not expressed at the mRNA level, and the gene for the TCR associated protein T3 delta is not detectably expressed at the mRNA or protein level in leukemias classified unambiguously as non-T. Five cases of acute leukemia with ambiguous or mixed lineage immunophenotypes (myeloid + T or myeloid + B) are described.
|
3118113 |
1987 |
Acute leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Its use allowed detection of previously unsuspected TCR alpha/delta rearrangements in 4/13 (30%) immature T-lineage acute leukemias, including two t(10;14) and 2 minor inversion 14s.
|
9242557 |
1997 |
Acute leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
PCR-based monitoring of minimal residual disease (MRD) in acute leukemias can be achieved via detection of fusion gene transcripts of chromosome aberrations or detection of immunoglobulin (Ig) and T cell receptor (TCR) gene rearrangements.
|
11896540 |
2002 |
Acute leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
T-cell receptor delta (TCR-delta) gene rearrangement was studied in 40 cases of acute leukaemia and lymphoma of T-cell lineage at diagnosis.
|
8756082 |
1996 |
Acute leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
To examine the distribution of rearrangements of the gamma- and beta-chain T-cell receptor (TCR) genes in T- and non-T acute lymphoblastic leukemias (ALLs), and potentially to determine which genes rearrange first in ontogeny, we analyzed high molecular weight DNA from 102 patients with acute leukemia.
|
2955409 |
1987 |