Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE We found TCR sequences that were used in multiple library wells from patients with T1D, but these sequences were private and not shared between individuals. 30082321 2018
Diabetes Mellitus, Insulin-Dependent
0.100 AlteredExpression disease BEFREE However, faster STAT3 activation after TCR stimulation without concomitant increase in IL-6 expression was observed in T cells from patients with T1D. 30006377 2018
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE Overall, KLRG1 expression delineates a subpopulation of dysfunctional T<sub>reg</sub> cells during T1D progression in autoantigen-specific TCR transgenic NOD mice. 28850267 2017
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE In this study, we directly compared the clonal iNKT repertoire of people with recent onset type 1 diabetes and age- and gender-matched healthy controls with regard to iNKT-TCR affinity and cytokine production. 28062695 2017
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE This study demonstrates the potential of TCR gene transfer to develop islet-specific Treg therapies for effective treatment of T1D, but also highlights that additional optimisation may be required to achieve its full potential. 28117148 2017
Diabetes Mellitus, Insulin-Dependent
0.100 GeneticVariation disease BEFREE There are skewd genes in TCR Vα and TCR Vβ, which are probably relative to the onset of T1D. 26479550 2016
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE Type 1 diabetes in BioBreeding rats is critically linked to an imbalance between Th17 and regulatory T cells and an altered TCR repertoire. 20644174 2010
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE These results provide evidence that new-onset patients with type 1 DM and healthy controls are primed against CVB4, and that CD4 T cell responses to the virus have a selective TCR Vbeta chain usage which is driven by viral Ags rather than a superantigen. 11544345 2001
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE We propose that a primary deficiency in human type 1 diabetes is a defect in TCR/CD3-mediated T cell activation due to the abnormal expression of the p56(lck) tyrosine kinase. 11067948 2000
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE We have overcome these difficulties by coupling a simplified TCR transgenic (tg) model of IDDM and the immunosuppressive drug cyclophosphamide (CY). 9933106 1999
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE Double transgenic (dTg) mice expressing the hemagglutinin (HA) of influenza virus under the insulin promoter and the TCR specific for the immunodominant CD4 T cell epitope of HA (HA110-120) develop insulin-dependent diabetes mellitus (IDDM). 10524496 1999
Diabetes Mellitus, Insulin-Dependent
0.100 AlteredExpression disease BEFREE These data support restricted TCRB gene usage in T cell populations enriched for in vivo activated clones in patients with IDDM. 10075863 1999
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE In order to clarify the nature of T lymphocytes infiltrating the pancreatic islets of patients with insulin-dependent diabetes mellitus (IDDM), we analysed T cell receptor (TCR) gene transcripts expressed in pancreatic biopsy specimens of patients with recent-onset IDDM. 8968689 1996
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE Polymorphism of the genes encoding the alpha, beta, and gamma chains of the human T-cell receptor (TCRA, TCRB, and TCRG), insulin gene (INS), and three closely linked polymorphic genes on chromosome 11q23, Thy-1 (THY1), T3-D (CD3D), and c-ets proto oncogene (ETS1) were investigated among 56 unrelated patients with insulin-dependent diabetes mellitus (IDDM) and 48 healthy controls. 1982251 1991
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE We investigated the T cell receptor constant beta chain (TCR C beta) genes of patients with insulin dependent diabetes mellitus (IDDM) using DNA restriction fragment length polymorphism (RFLP) analysis. 2891459 1987