Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis
0.100 Biomarker disease BEFREE In the current study, we systematically analyzed changes of the TCRβ repertoire driven by EAE and pregnancy using TCR sequencing. 31444265 2019
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis
0.100 Biomarker disease BEFREE Importantly, when co-transferred with myelin-specific 2D2 TCR-transgenic naive T cells, unrelated OT-II TCR-transgenic memory-like T<sub>H</sub>17 cells infiltrate the spinal cord and produce IL-17A, interferon (IFN)-γ, and GM-CSF, increasing the susceptibility of the recipients to experimental autoimmune encephalomyelitis in an IL-1 receptor-dependent manner. 30755603 2019
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis
0.100 Biomarker disease BEFREE Adoptive transfer of blastogenic CD25<sup>high</sup> FOXP3<sup>+</sup> Tregs from MOG35-55-specific 2D2 TCR transgenic mice suppressed experimental autoimmune encephalomyelitis in pretreatment and therapeutic protocols. 29312311 2017
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis
0.100 Biomarker disease BEFREE In TCR transgenic mice, the "EAE-susceptibility-associated" epitope was "ignored" by specific CD4 T cells, whereas the "resistance-associated" epitope induced clonal deletion and T<sub>reg</sub> induction in the thymus. 29170668 2017
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis
0.100 Biomarker disease BEFREE We evaluated the ability of a newly designed monomeric recombinant TCR ligand (RTL342M) containing HLA-DR2 peptide-binding domains covalently linked to MOG-35-55 peptide to prevent and treat both the initial episode and subsequent relapses of experimental autoimmune encephalomyelitis (EAE) in HLA-DR2 transgenic mice. 17257899 2007
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis
0.100 Biomarker disease BEFREE Mice transgenic for this human TCR and DRA and DRB1*1501 chains develop spontaneous experimental autoimmune encephalomyelitis. 15265898 2004
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis
0.100 Biomarker disease BEFREE Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice. 12816990 2003
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis
0.100 Biomarker disease BEFREE Transient genetic delivery of the TCR Vbeta8.2 chain protected mice from Ag-induced experimental autoimmune encephalomyelitis. 12517939 2003
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis
0.100 GeneticVariation disease BEFREE Major histocompatibility complex (MHC) class II and T-cell receptor (TCR) gene polymorphisms play important roles in rodent susceptibility to EAE and were analyzed to determine if the same was true in humans with SAE. 10319881 1999
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis
0.100 Biomarker disease BEFREE Diagnosis and assessment of preclinical and clinical autoimmune encephalomyelitis using peripheral blood lymphocyte TCR. 9754562 1998
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis
0.100 Biomarker disease BEFREE The extensive parallels between human T cells specific for V beta 5.2 and V beta 6.1 CDR2 peptides and rat T cells specific for V beta 8.2 CDR2 peptide that are highly protective against experimental encephalomyelitis strengthen the rationale for the therapeutic use of TCR peptides in human autoimmunity. 7510747 1994
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis
0.100 Biomarker disease BEFREE Immunization with disease-associated TCR V region peptides is an effective treatment for experimental autoimmune encephalomyelitis. 7510746 1994
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis
0.100 GeneticVariation disease BEFREE In order to establish whether such T cell responses are likely to be antigen-specific particularly with regard to myelin basic protein (MBP), we analysed T-cell receptor (TCR) gene rearrangements directly from MS brain plaques, using the polymerase chain reaction on reverse transcribed messenger RNA, and compared these with TCR of previously described MBP-specific T cell clones from MS and the rat model experimental allergic encephalomyelitis. 7680433 1993
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis
0.100 Biomarker disease BEFREE Synthetic peptides corresponding to germline TCR V beta 8.2 sequences overexpressed by Lewis rat encephalitogenic T cells are effective in the prevention and treatment of autoimmune encephalomyelitis (EAE). 7686833 1993