Hodgkin Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Monoclonally rearranged TCR-gamma genes were detectable in 2 of the 13 classic HD cases with T-cell marker-positive HRS cells, with none detectable in the null-cell cases.
|
10807764 |
2000 |
Hodgkin Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
TcR gene rearrangement may also be useful to distinguish Hodgkin's disease from T-cell non-Hodgkin's lymphoma.
|
8951602 |
1996 |
Hodgkin Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Combined immunophenotypic and immunogenotypic analyses showed a derivation from anomalously matured B cells in four of five CD30-positive ALC lymphomas, whereas SNCC showed features of mature B cells; no evidence of immunoglobulin or TCR gene rearrangement could be obtained in HD cases.
|
8617454 |
1996 |
Hodgkin Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although rearrangements of TCR gamma chain genes were shown in single cells of 10 of 10 T-cell leukemias, no rearrangement of these genes was found in single H&RS cells from 13 consecutive patients with HD.
|
7888676 |
1995 |
Hodgkin Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The structures of rearranged gamma-chain T-cell antigen receptor (TCR) genes were analyzed in 5 cases of T-cell acute lymphoblastic leukemia (T-ALL), in 15 cases of peripheral T-cell non-Hodgkin's lymphoma (T-NHL), in 1 case with large granular CD8 lymphocytosis, 1 case with CD8 lymphocytosis after autologous bone marrow transplantation for Hodgkin's disease, and in 2 cases with nonneoplastic diseases.
|
8025283 |
1994 |
Hodgkin Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The absence of Ig and TCR gene rearrangements seems to be common in HD, compared with in TRBL and incipient ATLL.
|
7874004 |
1994 |
Hodgkin Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine a possibly restricted TCR-V beta repertoire in reactive T-lymphocytes in Hodgkin's disease (HD), 20 cases (of which 10 were EBV-positive cases) were investigated using 14 monoclonal antibodies (MoAbs) recognizing 11 different TCR-V beta region family products and Northern blot analysis with cDNA probes specific for mRNA transcripts of 11 V beta families that were not detectable by MoAbs.
|
8043434 |
1994 |
Hodgkin Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
They concur in that rearranged Ig and T-cell receptor (TCR) genes are not demonstrable in most Hodgkin's disease (HD) cases.
|
8043859 |
1994 |
Hodgkin Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In DNA hybridization analysis, 5 of the 19 cases of HD were found to have gene rearrangements--immunoglobulin (Ig) gene rearrangements in 3 cases and T cell receptor beta chain (TCR beta) gene rearrangements in 2 cases.
|
8395909 |
1993 |
Hodgkin Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study of 52 Swiss patients with Hodgkin's disease (HD), including 17 cases with a high content of Sternberg-Reed (SR) and Hodgkin (H) cells, was performed to determine the percentage of cases harboring Epstein-Barr virus (EBV) DNA and/or clonal rearrangements of Ig and T-cell antigen receptor (TcR) genes in diagnostic lymph node biopsies.
|
1650264 |
1991 |
Hodgkin Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Two cases of Hodgkin's disease showed no rearrangement of the Ig and TCR genes.
|
2208029 |
1990 |
Hodgkin Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The authors report the detailed analysis of tumor tissue DNA obtained from 18 cases of HD using Ig and TCR gene probes.
|
3358458 |
1988 |
Hodgkin Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
We can explain these results in at least three ways: first, the neoplastic population could represent less than 1% of the total, thus escaping detection by current techniques; second, the neoplastic population is not lymphoid in nature or is composed of mature cells that do not rearrange Ig and TCR genes and therefore belongs to a true non-B, non-T lineage; third, the pathogenesis of HD is completely different from that of non-Hodgkin's lymphomas (NHL) and does not involve the clonal expansion of a cell frozen at a particular maturative stage as is thought to happen in most NHL.
|
3132516 |
1988 |
Hodgkin Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Only 5 samples of HD [2 of lymphocytic predominance (HDLP), 2 of mixed cellularity (HDMC), and one of nodular sclerosis type (HDNS)] were found to have both their Ig and T-cell antigen receptor (TcR) genes in the germ-line configuration.
|
3112031 |
1987 |
Hodgkin Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Of special interest was the finding that some cases of Hodgkin's lymphoma and AIL contain clonal rearrangement of the TcR genes, which suggests that in those cases the malignant cells may be of T cell origin.
|
3771790 |
1986 |