Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE TCRs genetically linked to CD28 and CD3ε do not mispair with endogenous TCR chains and mediate enhanced T cell persistence and anti-melanoma activity. 25320284 2015
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE The feasibility of T-Cell receptor (TCR) gene therapy using a MART-1-specific TCR has been previously demonstrated in melanoma patients. 25174578 2015
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE Here, we evaluated unique phenotypic traits of CD8⁺ TILs and TCR β chain (TCRβ) clonotypic frequency in melanoma tumors to identify patient-specific repertoires of tumor-reactive CD8⁺ lymphocytes. 24667641 2014
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE TCR gene transfer: MAGE-C2/HLA-A2 and MAGE-A3/HLA-DP4 epitopes as melanoma-specific immune targets. 22400038 2013
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE In this review, we discuss the progress and prospects of TCR gene-engineered T cells as a therapeutic strategy for treating patients with melanoma and other cancers. 22178904 2012
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE Expression of both TCRs in human PBLs demonstrated Ag-specific reactivity against a range of melanoma and nonmelanoma tumor cells. 21149604 2011
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE MHC class I-restricted human melanoma epitope MART-1(27-35) specific TCR-engineered CD4+CD25- T cells synthesize Th1 type cytokines and exhibit cytolytic effector function upon cognate stimulation. 20547105 2010
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE These results suggest that this highly active tyrosinase-specific TCR could be of value in adoptive cell transfer for melanoma. 20427771 2010
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE T cell receptor (TCR) gene therapy to treat melanoma: lessons from clinical and preclinical studies. 20146634 2010
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE However, the addition of ABT-737 to either a vaccine strategy involving priming with TRP-2 melanoma antigen peptide-pulsed DC and boosting with recombinant Listeria monocytogenes expressing the same melanoma antigen, or the adoptive transfer of TCR transgenic cells, did not result in superior antitumor activity against B16 murine melanoma. 18807035 2009
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE Residual melanoma within the wide local excision specimen is associated with TCR zeta loss in noninvolved sentinel lymph nodes, suggesting that immune modulation precedes tumor spread. 18245524 2008
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE A recent trial in humans demonstrated that TCR gene-modified T cells persisted in all and reduced melanoma burden in 2/15 patients. 17637721 2008
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE We propose that inducing expression of this highly avid TCR in patient PBMC has the potential to induce tumor regression, as an "off-the-shelf" reagent for allogeneic melanoma patient gene therapy. 17056587 2006
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE CD8 alpha coreceptor to improve TCR gene transfer to treat melanoma: down-regulation of tumor-specific production of IL-4, IL-5, and IL-10. 16818755 2006
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE To better understand the role of individual T cell clones in mediating tumor regression, a 5' RACE technique was used to determine the distribution of TCR beta-chain V region sequences expressed in the transferred cells as well as in tumor samples and circulating lymphocytes from melanoma patients following adoptive cell transfer. 15585890 2005
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE High efficiency TCR gene transfer into primary human lymphocytes affords avid recognition of melanoma tumor antigen glycoprotein 100 and does not alter the recognition of autologous melanoma antigens. 12960359 2003
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE Selective targeting of melanoma and APCs using a recombinant antibody with TCR-like specificity directed toward a melanoma differentiation antigen. 12928363 2003
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE To gain insight into these questions, we performed a functional and structural longitudinal analysis of the TCR of circulating CD8(+) T cells specific for the HLA-A2-restricted immunodominant epitope from the melanocyte differentiation Ag Melan-A in a melanoma patient who developed a vigorous and sustained Ag-specific T cell response following vaccination with the corresponding synthetic peptide. 11937585 2002
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE Three domain single chain (sc-) TCR as well as two chain (tc-) TCR gene constructs were derived from the melanoma-specific cytotoxic human T cell (CTL) clone 82/30, and linked to the CD3-zeta signaling element. 10981663 2000
CUI: C0025202
Disease: melanoma
melanoma
0.100 GeneticVariation disease BEFREE To address this issue, we compared the T cell receptor (TCR) gene usage, complementary-determining region 3 diversity, and melanoma-associated antigens expression patterns of primary and metastatic melanoma specimens from three patients with partially homologous HLA class-1 types. 9856821 1999
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE Conserved TCR usage by HLA-Cw* 1601-restricted T cell clones recognizing melanoma antigens. 8921424 1997
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE These results indicate that a selective repertoire of TCR genes is used in anti-melanoma responses when the response is narrowed to major histocompatibility complex-restricted antigen-specific interactions. 7777568 1995
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE Overexpression of the T-cell receptor beta-chain variable region TCRBV14 in HLA-A2-matched primary human melanomas. 7614474 1995
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE A PCR-based method that determines VDJ junction size patterns in 24 human TCR V beta subfamilies was used to analyze T cells infiltrating sequential malignant melanoma biopsies for the presence of clonal expansions. 8077684 1994
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE The restricted usage of TCR genes in TIL may indicate that a specific antigen in these melanomas is targeted. 2382141 1990