Sezary Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The malignant SS clone was identified as TCR Vα2-Jα22 rearrangement without deletion at the A20 loci (6q23-27 region) in the SS case.
|
28296250 |
2018 |
Sezary Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The lack of clear stereotypic TCRA and TCRB CDR3 amino acid motifs would argue against involvement of a single common antigen in the pathogenesis of SS.
|
21410672 |
2011 |
Sezary Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Peripheral blood mononuclear cells were obtained from a patient with SS, stained with anti-T-cell receptor Vb (TCR-Vb) antibodies, and sorted by multiparameter flow cytometry.
|
20698843 |
2010 |
Sezary Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Molecular staging in MF and SS using a PCR-based method for TCR gene analysis provides additional information to histological examination.
|
16965425 |
2006 |
Sezary Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have examined in detail the features of the T-cell receptor beta (TCRB) gene rearrangements in 20 individuals with well-defined stages of cutaneous T-cell lymphoma (CTCL) comprising 10 cases with early-stage mycosis fungoides (MF) and 10 cases with late-stage MF or Sezary syndrome.
|
16741518 |
2006 |
Sezary Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The authors suggest that the definitive diagnostic criteria for patients with SS should include the presence of a clonal TCR gene rearrangement.
|
11745245 |
2001 |
Sezary Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Four biopsies, from three patients, contained clonal TCR-gamma rearrangements; the four biopsies, all of which were equivocal histologically, correlated to diagnoses of mycosis fungoides (MF) or Sézary syndrome (SS).
|
11437940 |
2001 |
Sezary Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To determine if circulating Sezary cells can be classified as reactive or neoplastic based on the ability to detect the presence or absence of clonal T-cell receptor beta chain (TCR-beta) gene rearrangements by Southern blot analysis, we evaluated the peripheral blood of 25 patients: 11 patients with Sezary syndrome (SS), 11 with benign inflammatory dermatoses (BID), and three normal controls.
|
7492785 |
1995 |
Sezary Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The goal of our study was to molecularly diagnose CTCL, by cloning the T-cell antigen receptor beta chain (TCR-beta) gene rearrangement from the malignant T cells of a patient with Sézary syndrome, in order to generate a specific oligonucleotide probe capable of detecting CTCL cells through polymerase chain reaction (PCR) amplification.
|
1848269 |
1991 |
Sezary Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the two "false-negative" cases of SS clonal TCR beta gene rearrangements were detected in PBL obtained during follow-up.
|
1655913 |
1991 |
Sezary Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nine patients had acute lymphoblastic leukaemia (T-ALL), nine patients had prolymphocytic leukaemia (PLL), six patients presented with a T-CLL/T-lymphocytosis syndrome, two patients had Sezary syndrome (SS) and one patient had HTLV-I positive T-cell leukaemia/lymphoma (ATLL). alpha TCR gene rearrangement could be demonstrated by the use of three available probes in only one case.
|
2961364 |
1987 |