Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.050 Biomarker disease BEFREE And severe patients in our AS cohort have a more restricted TCR repertoire than mild patients, suggesting that the TCR repertoire diversity might be associated with the clinical severity of disease. 29614337 2018
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.050 Biomarker disease BEFREE The best evidence is for major histocompatibility complex class I chain-related gene A (MICA) whose recognition by intestinal epithelial T cells expressing different V-delta-1 gamma/delta TCR further implicates the gut in AS pathogenesis. 24838411 2014
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.050 Biomarker disease BEFREE Search for the TCR V beta CRD3 sequences homologous to the identified clones revealed close matches with the previously reported T cell clones from AS and reactive arthritis patients, thus supporting their role in the disease and proposing consensus TCR V beta CDR3 motifs for AS. 19657773 2009
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.050 Biomarker disease BEFREE To determine whether the T cell repertoires of individuals with AS show signs of increased stimulation by exogenous antigens, CD4+ and CD8+ T cell subsets of five monozygotic HLA-B27+ twins (two concordant and three discordant for AS) and CD8+ T cell repertoires of three healthy HLA-B27+ individuals were characterized by TCR beta-chain (TCRB) CDR3 size spectratyping. 11207664 2001
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.050 GeneticVariation disease BEFREE It is unlikely that either the TCRA/D or TCRB loci contain genes responsible for more than a moderate proportion of the non-MHC genetic susceptibility to ankylosing spondylitis. 9619899 1998