Disease: T-Cell Lymphoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE The Ig/TCR gene rearrangement of BIOMED-2 multiplex PCR strategy has important auxiliary value in the diagnosis of B/T-cell non-Hodgkin lymphoma respectively, however, a few B-cell lymphomas may company TCR gene rearrangement as well as a few T-cell lymphomas may accompany Ig gene rearrangement, it must be comprehensively judged with the combination of morphology, immunohistochemistry and clinical features. 31562020 2019
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 AlteredExpression disease BEFREE Although the neoplastic cells of extranodal natural killer (NK)/T-cell lymphoma (ENKTL) usually do not express T-cell antigens, the T-cell receptor (TCR) gene might be rearranged and TCR protein expressed. 30102799 2018
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE TCR gene transcripts were positive in ENKTLs as well as in normal B cells and aggressive NK-cell leukemia. 27015135 2016
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE This TCR-V(β)-R strategy is valuable in staging and evaluating MRD in patients with T-cell non-Hodgkin lymphoma. 22261447 2012
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 GeneticVariation disease BEFREE Therefore, detection of immunoglobulin heavy chain (IgH) and T-cell receptor (TCR) gene rearrangements provide molecular diagnosis of B- and T-cell lymphoma, respectively. 22016619 2011
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE In an otherwise normal thymic environment, PTEN-deficient T cell lymphomas invariably harbored RAG-dependent reciprocal t(14:15) chromosomal translocations involving the T cell receptor alpha/delta locus and c-myc, and their survival and growth was TCR dependent, but Notch independent. 20516645 2010
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE In addition, three of the five tested precursor T-cell lymphoblastic lymphomas showed no TCR gene clonality, probably because the immature T-cells in this type of TCL had not undergone TCR gene rearrangements. 20233058 2010
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 GeneticVariation disease BEFREE Surprisingly, ≈50% of mice with prerearranged TCR genes develop spontaneous T cell lymphomas, which originate in the thymus. 20956329 2010
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE A clonal T-cell rearrangement by T-cell receptor gamma chain polymerase chain reaction (TCR-gamma PCR) was identified in 1 case in which insufficient events were present for evaluation by flow cytometry and in 1 case in which flow cytometry was not diagnostic of T-cell lymphoma. 18798522 2008
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE Primary CD20+CD10+CD8+ T-cell lymphoma of the skin with IgH and TCR beta gene rearrangement. 16753590 2006
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 GeneticVariation disease BEFREE Natural killer (NK)/T-cell lymphomas are frequently associated with Epstein-Barr virus (EBV), and usually lack TCR gene rearrangement. 14989738 2004
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE Humoral immunoreaction induced by TCR DNA vaccine for beta chain of T cell lymphoma. 15121317 2004
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE To identify such mixed-lineage lymphomas, we undertook a survey of 15 consecutive sinonasal lymphomas and found six with both a restricted KIR repertoire and a monoclonal TCR-gamma rearrangement, consistent with KIR(+) T-cell lymphomas. 12533686 2003
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 GeneticVariation disease BEFREE In the CD56+ cutaneous nasal-type NK/T-cell lymphoma strongly associated with latent EBV infection, subcutaneous or dermal nodules are the most common skin findings, but great morphologic heterogeneity has been noted including papules, infiltrated plaques, and ulcerated tumors, and TCR genes are mostly germline. 12432997 2002
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE TCR-gamma PCR is a complementary tool for the assessment of T-cell lymphoma in bone marrow biopsies. 11135045 2001
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE The identification of clonal rearrangements of T cell receptor (TCR) genes is central to the diagnosis of T cell lymphomas. 10666395 2000
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE Using DNA capillary gel electrophoresis, we examined the spectrum of normal patterns for TCR-gamma in a variety of T-cell-rich, histologically benign tissue types, including spleen, lymph node, tonsil, and blood, and compared this with the patterns in T cell lymphoma samples. 11229519 2000
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE We propose a novel diagnostic technique based on restriction fragment length polymorphism (RFLP) of amplified polymerase chain reaction (PCR) products of the T-cell receptor -gamma (TCR-gamma) gene rearrangement to rapidly identify monoclonality in T-cell lymphomas and improve diagnosis of malignancy. 10423334 1999
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE Six of the 7 (86%) T-ALL and 4 of the 5 (80%) T-cell lymphoma which were Southern positive were also positive by TCR delta PCR. 9209365 1997
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 GeneticVariation disease BEFREE In conclusion, the results of this study suggest that demonstration of clonal TCR gene rearrangements and an aberrant phenotype, as well as demonstration of many admixed CD8+ T cells and B cells can be considered as useful additional criteria in the differentiation between pseudo-T-cell lymphomas and CTCLs. 9176388 1997
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE TcR gene rearrangement may also be useful to distinguish Hodgkin's disease from T-cell non-Hodgkin's lymphoma. 8951602 1996
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE We investigated the arrangement of Ig and T-cell receptor (TCR) genes, together with the involvement of several oncogenes and the tumor-suppressor gene p53, in a panel of primary cutaneous B- and T-cell lymphomas (CBCLs and CTCLs). 7579411 1995
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 GeneticVariation disease BEFREE The structures of rearranged gamma-chain T-cell antigen receptor (TCR) genes were analyzed in 5 cases of T-cell acute lymphoblastic leukemia (T-ALL), in 15 cases of peripheral T-cell non-Hodgkin's lymphoma (T-NHL), in 1 case with large granular CD8 lymphocytosis, 1 case with CD8 lymphocytosis after autologous bone marrow transplantation for Hodgkin's disease, and in 2 cases with nonneoplastic diseases. 8025283 1994
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 GeneticVariation disease BEFREE The first clone was characterized by a reciprocal translocation t(5;7)(q13;q35) involving 7q35, namely the TCR-beta gene, as expected in T-cell lymphomas. 8133397 1993
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 GeneticVariation disease BEFREE A beta-TCR clonal rearrangement was found in 19 of 19 tumor samples considered as malignant T-cell lymphoma on the basis of histopathology and of the CD3-positive phenotype of tumoral cells, and in two cases of CD3-positive lymphomatoid disorders. 3196872 1988