Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085669
Disease: Acute leukemia
Acute leukemia
0.100 Biomarker disease BEFREE PCR-based monitoring of minimal residual disease (MRD) in acute leukemias can be achieved via detection of fusion gene transcripts of chromosome aberrations or detection of immunoglobulin (Ig) and T cell receptor (TCR) gene rearrangements. 11896540 2002
CUI: C0085669
Disease: Acute leukemia
Acute leukemia
0.100 Biomarker disease BEFREE Its use allowed detection of previously unsuspected TCR alpha/delta rearrangements in 4/13 (30%) immature T-lineage acute leukemias, including two t(10;14) and 2 minor inversion 14s. 9242557 1997
CUI: C0085669
Disease: Acute leukemia
Acute leukemia
0.100 GeneticVariation disease BEFREE These 29 acute leukaemias exhibiting TCR delta gene rearrangements were selected from 66 Ly+ AML, 14 My+ T-ALL and 12 My(-) T-ALL cases. 8616087 1996
CUI: C0085669
Disease: Acute leukemia
Acute leukemia
0.100 Biomarker disease BEFREE T-cell receptor delta (TCR-delta) gene rearrangement was studied in 40 cases of acute leukaemia and lymphoma of T-cell lineage at diagnosis. 8756082 1996
CUI: C0085669
Disease: Acute leukemia
Acute leukemia
0.100 GeneticVariation disease BEFREE By screening for immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangements in bone marrow samples aspirated at different time points during the course of disease from 43 patients with acute leukaemia we have analysed the extent of clonal evolution after autologous bone marrow transplantation (ABMT) and addressed the issue of whether the Southern Blot method has the power to reveal clonal proliferations representing minimal residual disease (MRD) in the autologous bone marrow grafts. 8698127 1996
CUI: C0085669
Disease: Acute leukemia
Acute leukemia
0.100 GeneticVariation disease BEFREE In order to clarify whether HTLV-I plays a role as a virus-encoded superantigen in the neoplastic process, we examined the TCR V beta families in the peripheral blood at four different clinical stages: carrier, smoldering leukemia, chronic leukemia, and acute leukemia. 8638605 1996
CUI: C0085669
Disease: Acute leukemia
Acute leukemia
0.100 GeneticVariation disease BEFREE Clonal diversity, measured by heterogeneity of Ig and TCR gene rearrangements, in some acute leukaemias of childhood is associated with a more aggressive disease. 7786608 1995
CUI: C0085669
Disease: Acute leukemia
Acute leukemia
0.100 GeneticVariation disease BEFREE Five cases of acute leukemia (AL) with the t(4;11) translocation were investigated for the immunoglobulin heavy chain, kappa, lambda, TCR beta and TCR gamma gene rearrangements. 1375695 1992
CUI: C0085669
Disease: Acute leukemia
Acute leukemia
0.100 GeneticVariation disease BEFREE Our findings suggest that the coexistence of JH and TcR gene rearrangements, frequently detected in acute leukemia, may also be observed in hematologic malignancies derived from more differentiated cells. 1847340 1991
CUI: C0085669
Disease: Acute leukemia
Acute leukemia
0.100 Biomarker disease BEFREE To examine the distribution of rearrangements of the gamma- and beta-chain T-cell receptor (TCR) genes in T- and non-T acute lymphoblastic leukemias (ALLs), and potentially to determine which genes rearrange first in ontogeny, we analyzed high molecular weight DNA from 102 patients with acute leukemia. 2955409 1987
CUI: C0085669
Disease: Acute leukemia
Acute leukemia
0.100 AlteredExpression disease BEFREE Inappropriately rearranged IgH or TCR genes are usually not expressed at the mRNA level, and the gene for the TCR associated protein T3 delta is not detectably expressed at the mRNA or protein level in leukemias classified unambiguously as non-T. Five cases of acute leukemia with ambiguous or mixed lineage immunophenotypes (myeloid + T or myeloid + B) are described. 3118113 1987