Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Multivariate analysis incorporating tumor status based on the presence of <i>IDH</i> mutations, <i>TERT</i> promoter mutations, and 1p/19q codeletion showed that in lower-grade gliomas, high NLR predicted poorer survival for the triple-negative, IDH mutation only, TERT mutation only, and IDH and TERT mutation groups.
|
31444316 |
2019 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the association between TERT and ATRX in World Health Organization (WHO) grade II to IV glioma remains unclear.
|
30655743 |
2019 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results revealed that the expression levels of HHLA2 were significantly lower in high‑grade glioma, as well as glioma with wild‑type isocitrate dehydrogenase, no deletion of 1p/19q and telomerase reverse transcriptase promoter mutation.
|
31578594 |
2019 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
EGFR was significantly associated with all glioma and glioblastoma in males only and a female-specific association in TERT, all of which remained nominally significant after conditioning on known risk loci.
|
30124908 |
2019 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
TERT expression is susceptible to BRAF and ETS-factor inhibition in BRAF<sup>V600E</sup>/TERT promoter double-mutated glioma.
|
31391125 |
2019 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using our newly developed TERT-specific monoclonal antibody (TMab-6) applicable to human tissue, we found an unexpected increase in TERT expression in <i>TERT</i>-wildtype as well as <i>TERT</i>-mutated gliomas and in tumor vasculature.
|
29693015 |
2018 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
This article reviews recent research on (1) the mechanism of TERT activation in glioma, (2) downstream consequences of TERT overexpression on glioma pathogenesis, and (3) targeting TPMs as a therapeutic strategy.
|
29525892 |
2018 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The clinical significance of telomerase reverse transcriptase (TERT) promoter mutation in glioma remains unclear.
|
29198322 |
2017 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Triple-positive (IDH1 and TERT mutation with 1p19q codeletion) glioma tended to be oligodendroglioma present with much better clinical outcome compared to TERT mutation only group who is glioblastoma inclined (median overall survival 39 months VS 18 months).
|
28915860 |
2017 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Univariate analyses showed that ACYP2 rs12615793 and TERT rs2853676 loci affected progression-free survival in glioma patients; both ZNF208 rs8105767 and ACYP2 rs843720 affected the OS of patients with low-grade gliomas.
|
28985021 |
2017 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The pooled results calculated by fixed-effects model suggested that TERT mutations were associated with poor prognosis of glioma patients (HR 1.68, 95 % CI 1.43-1.97).
|
27206431 |
2017 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Coherent with in vitro findings, pharmacological inhibition of TERT by costunolide decreased lipid accumulation and elevated ATM expression in heterotypic xenograft glioma mouse model.
|
28833137 |
2017 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the five subtypes were classified based on the prognostic impact of the TERT mutation with different genetic backgrounds of glioma.
|
28868656 |
2017 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We used data for 1206 patients from the UCSF Adult Glioma Study, the Mayo Clinic and The Cancer Genome Atlas (TCGA) with infiltrative glioma, grades II-IV for whom tumor status for IDH, 1p/19q codeletion, ATRX, and TERT had been determined.
|
28255664 |
2017 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Previous studies have found that telomerase reverse transcriptase (TERT) has vital roles in the development of malignant diseases including glioma.
|
26351078 |
2016 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increasing evidences have implicated somatic gain-of-function mutations at the telomerase reverse transcriptase (TERT) promoter as one of the major mechanisms that promote transcriptional activation of TERT and subsequently maintain telomere length in human cancers including glioma.
|
26556853 |
2016 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our study indicates that TERT rs2853676 polymorphisms correlate with glioma survival and recurrence rates in a Chinese population, which suggests that they could potentially serve as prognostic markers in glioma patients.
|
27655710 |
2016 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
TERT polymorphisms were associated with an increased risk of glioma compared to controls (RR=1.28, 95% CI 1.23-1.33).
|
26765760 |
2016 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggests that the TERT genetic polymorphism rs2853676 is associated with increased risk of glioma, lung adenocarcinoma and ovarian cancer among Caucasians.
|
26042809 |
2015 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Four LTL-associated SNPs were significantly associated with glioma risk in pooled analyses, including those in the telomerase component genes TERC (O.R.=1.14; 95% C.I.=1.03-1.28) and TERT (O.R.=1.39; 95% C.I.=1.27-1.52), and those in the CST complex genes OBFC1 (O.R.=1.18; 95% C.I.=1.05-1.33) and CTC1 (O.R.=1.14; 95% C.I.=1.02-1.28).
|
26646793 |
2015 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that PinX1 obviously reduced the gliomas cell proliferation through regulating the expressions of cell cycle-relative molecules to arrest cell at G1 phase and down-regulating the expression of component telomerase reverse transcriptase (hTERT in human), which is the hardcore of telomerase.
|
25698538 |
2015 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, grades II and III gliomas harboring TERTp mutation were located preferentially in the frontal lobe and rarely in midline.
|
26617880 |
2015 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Common inherited variants near the telomerase-component genes TERC and TERT are associated both with longer telomere length and increased risk of glioma.
|
26014050 |
2015 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The role of telomerase reverse transcriptase (TERT) in gliomagenesis has been recently further strengthened by the frequent occurrence of TERT promoter mutations (TERTp-mut) in gliomas and evidence that the TERT SNP genetic rs2736100 influences glioma risk.
|
25314060 |
2014 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Frequent mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) and the promoter of telomerase reverse transcriptase (TERT) represent two significant discoveries in glioma genomics.
|
24722048 |
2014 |