Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
TCGA data revealed that early NSCLC patients with higher expression level of TERT mRNA in lung tumor tissues had a longer MST and decreased death risk than those with low expression level of TERT mRNA [MST=54.4 vs 49.0 months; log-rank P=0.041; adjusted HR (95% CI)=0.68(0.50-0.94)].
|
27982019 |
2017 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Sequence variants at the TERT-CLPTM1L locus associate with many cancer types.
|
19151717 |
2009 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Telomerase activity in transthoracic fine-needle biopsy aspirates from non-small cell lung cancer as prognostic factor of patients' survival.
|
18063440 |
2008 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Lung cancer susceptibility locus at 5p15.33.
|
18978790 |
2008 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Tumor-specific activation of human telomerase reverses transcriptase promoter activity by activating enhancer-binding protein-2beta in human lung cancer cells.
|
17630431 |
2007 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Amplification of telomerase (hTERT) gene is a poor prognostic marker in non-small-cell lung cancer.
|
16641908 |
2006 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Injection of mTERT siRNA:SWNT+ complexes into s.c. Lewis lung tumors reduced tumor growth.
|
16914582 |
2006 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
To evaluate the prognostic value of the catalytic subunit telomerase reverse transcriptase (hTERT), we analysed its expression by immunohistochemistry in 122 formalin-fixed lung tumours including 42 squamous cell carcinoma (SCC), 43 adenocarcinoma (ADC), 19 basaloid carcinoma (BC) and 18 small-cell lung carcinoma (SCLC) in comparison with detection of hTERT mRNA by in situ hybridisation and relative telomerase activity by TRAP assay in a subset of tumours.
|
15026805 |
2004 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Retinoic acid receptor beta and telomerase catalytic subunit expression in bronchial epithelium of heavy smokers.
|
12529350 |
2003 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
[Relationship between human telomerase reverse transcriptase transcriptional level and telomerase activity in three ovarian cancer cell lines].
|
12753708 |
2003 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
[Inhibition of telomerase activity and induction of apoptosis in lung cancer cell by human telomerase reverse transcriptase gene antisense oligodeoxynucleotide].
|
11940318 |
2002 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
hTERT expression is a prognostic factor of survival in patients with stage I non-small cell lung cancer.
|
12231532 |
2002 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Telomerase activation and p53 mutations in urethane-induced A/J mouse lung tumor development.
|
11323394 |
2001 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Amplification of the hTERT gene was observed in 8 of 26 (31%) tumor cell lines and 17 of 58 (30%) primary tumors examined (8 of 21 lung tumors, 3 of 10 cervical tumors, 5 of 19 breast carcinomas, and 1 of 8 neuroblastomas).
|
11103775 |
2000 |