TERT, telomerase reverse transcriptase, 7015

N. diseases: 703; N. variants: 97
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 AlteredExpression group BEFREE TCGA data revealed that early NSCLC patients with higher expression level of TERT mRNA in lung tumor tissues had a longer MST and decreased death risk than those with low expression level of TERT mRNA [MST=54.4 vs 49.0 months; log-rank P=0.041; adjusted HR (95% CI)=0.68(0.50-0.94)]. 27982019 2017
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 Biomarker group CTD_human Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. 19151717 2009
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 AlteredExpression group LHGDN Telomerase activity in transthoracic fine-needle biopsy aspirates from non-small cell lung cancer as prognostic factor of patients' survival. 18063440 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 Biomarker group LHGDN Lung cancer susceptibility locus at 5p15.33. 18978790 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 AlteredExpression group LHGDN Tumor-specific activation of human telomerase reverses transcriptase promoter activity by activating enhancer-binding protein-2beta in human lung cancer cells. 17630431 2007
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 AlteredExpression group LHGDN Amplification of telomerase (hTERT) gene is a poor prognostic marker in non-small-cell lung cancer. 16641908 2006
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 Biomarker group BEFREE Injection of mTERT siRNA:SWNT+ complexes into s.c. Lewis lung tumors reduced tumor growth. 16914582 2006
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 AlteredExpression group BEFREE To evaluate the prognostic value of the catalytic subunit telomerase reverse transcriptase (hTERT), we analysed its expression by immunohistochemistry in 122 formalin-fixed lung tumours including 42 squamous cell carcinoma (SCC), 43 adenocarcinoma (ADC), 19 basaloid carcinoma (BC) and 18 small-cell lung carcinoma (SCLC) in comparison with detection of hTERT mRNA by in situ hybridisation and relative telomerase activity by TRAP assay in a subset of tumours. 15026805 2004
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 AlteredExpression group LHGDN Retinoic acid receptor beta and telomerase catalytic subunit expression in bronchial epithelium of heavy smokers. 12529350 2003
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 AlteredExpression group LHGDN [Relationship between human telomerase reverse transcriptase transcriptional level and telomerase activity in three ovarian cancer cell lines]. 12753708 2003
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 AlteredExpression group LHGDN [Inhibition of telomerase activity and induction of apoptosis in lung cancer cell by human telomerase reverse transcriptase gene antisense oligodeoxynucleotide]. 11940318 2002
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 AlteredExpression group LHGDN hTERT expression is a prognostic factor of survival in patients with stage I non-small cell lung cancer. 12231532 2002
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 Biomarker group CTD_human Telomerase activation and p53 mutations in urethane-induced A/J mouse lung tumor development. 11323394 2001
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 GeneticVariation group BEFREE Amplification of the hTERT gene was observed in 8 of 26 (31%) tumor cell lines and 17 of 58 (30%) primary tumors examined (8 of 21 lung tumors, 3 of 10 cervical tumors, 5 of 19 breast carcinomas, and 1 of 8 neuroblastomas). 11103775 2000