Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 Biomarker disease BEFREE In this report, we found a rare case of RCC with a fusion between 5' EWSR1 and 3' TFE3. 31774608 2020
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 GeneticVariation disease BEFREE Ten patients with RBM10-TFE3 RCC aged 31-71 years were investigated. 30908700 2019
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 GeneticVariation disease BEFREE To broaden the spectrum of Xp11 neoplasms, we investigated a novel tumor exhibiting morphologies overlapping Xp11.2 translocation/TFE3 rearrangement-associated RCC and the mesenchymal counterpart with melanocytic differentiation by immunohistochemistry, fluorescence in situ hybridization (FISH) and RNA sequencing, as well as literature review. 31277953 2019
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 GeneticVariation disease BEFREE The diagnosis was TFE3/Xp11.2 translocation RCC. 28478739 2019
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 GeneticVariation disease BEFREE Xp11.2 translocation/TFE3 gene fusion renal cell carcinoma with a micropapillary pattern: cases report and literature review. 30787990 2019
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 Biomarker disease BEFREE Dual mTORC1/2 inhibition suppresses Akt/mTOR signaling more effectively than selective mTORC1 inhibition and demonstrates in vivo preclinical efficacy against TFE3-fusion renal cell carcinoma. 31519159 2019
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 GeneticVariation disease BEFREE Transcription factor E3 (TFE3) is a useful marker for tumors with Xp11.2 translocation, including alveolar soft part sarcoma and renal cell carcinoma. 31788112 2019
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 GeneticVariation disease BEFREE Xp11.2 translocation renal cell carcinoma (Xp11tRCC) is a subtype of renal cell carcinoma (RCC) characterized by chromosomal rearrangement of the region harboring the transcription factor for immunoglobulin heavy-chain enhancer 3 (TFE3). 31153695 2019
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 Biomarker disease BEFREE Among the 27 renal cell carcinomas with TFE3 strong positive immunostaining, 20 cases were diagnosed as Xp11 translocation renal cell carcinoma, and seven cases were diagnosed as clear cell renal cell carcinoma. 31175325 2019
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 GeneticVariation disease BEFREE Magnetic resonance imaging findings of renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion in adults: a pilot study. 30019296 2019
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 Biomarker disease BEFREE The KAT6A-TFE3 renal cell carcinoma demonstrated typical morphological features of TFE3/Xp11 renal cell carcinoma including papillae, eosinophilic cytoplasm with focal clearing and abundant psammoma bodies. 30622287 2019
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 GeneticVariation disease BEFREE Nevertheless, the subtyping process can be more complex in some cases: differential diagnosis (CCRCC or TFE3 TRCC, PRCC or TFE3 TRCC, oncocytic tumors corresponding to ChRCC or oncocytoma), molecular confirmation (TFEB TRCC) and unclassified RCC. 31437522 2019
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 Biomarker disease BEFREE The TFE3-RCC mouse provides a preclinical <i>in vivo</i> model for the development of new biomarkers and targeted therapeutics for patients affected with this aggressive form of RCC. 31043488 2019
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 AlteredExpression disease BEFREE The TCGA data set of renal cell carcinoma was evaluated to validate TFE3 expression and survival analysis. 29968390 2018
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 Biomarker disease BEFREE We report a case of a 44-year-old man who has been treated with everolimus for a Xp11.2 translocation/TFE3 gene-fusion RCC after 2 previous failed treatments with tyrosine kinase inhibitor. 29702156 2018
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 Biomarker disease BEFREE This is the first time to correlate the MED15-TFE3 renal cell carcinoma with specific clinicopathologic features. 29713041 2018
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 Biomarker disease BEFREE Metastatic TFE3-overexpressing renal clear cell carcinoma with dense granules: a histological, immunohistochemical, and ultrastructural study. 30040522 2018
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 GeneticVariation disease BEFREE Adult-onset renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion: 3 case reports and review of literature. 29901594 2018
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 GeneticVariation disease BEFREE Two transcription factors in this family have been identified in two unusual types of renal cell carcinoma (RCC): Xp11 translocation RCC harbouring TFE3 gene fusions and t(6;11) RCC harbouring a MALAT1-TFEB gene fusion. 29148086 2018
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 GeneticVariation disease BEFREE Cyto-histological correlation of Xp11.2 translocation/TFE3 gene fusion associated renal cell carcinoma: Report of a case with review of literature. 29024535 2018
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 GeneticVariation disease BEFREE Preoperative neutrophil-to-lymphocyte ratio predicts the surgical outcome of Xp11.2 translocation/TFE3 renal cell carcinoma patients. 29890986 2018
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 GeneticVariation disease BEFREE Herein, we examined 5 additional cases of SFPQ-TFE3 RCCs using clinicopathologic, immunohistochemical, and molecular analyses. 28315422 2017
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 AlteredExpression disease BEFREE We evaluated the frequency of translocation renal cell carcinoma (RCC) by reverse transcription polymerase chain reaction (RT-PCR) and how well the TFE3 immunoreactivity is concordant with TFE3 gene translocation status proved by fluorescence in situ hybridization (FISH) assay and RT-PCR. 28415646 2017
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 Biomarker disease BEFREE All 7 PRCC-TFE3 RCCs showed positive cathepsin K immunoreactivity. 28949976 2017
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 GeneticVariation disease BEFREE Cytogenetic studies confirmed the diagnosis of Xp11.2 translocation-associated RCC with positive TFE3 gene rearrangement. 28877071 2017