Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney
0.100 Biomarker disease BEFREE Translocation renal cell carcinoma (tRCC) represents a rare subtype of kidney cancer associated with various <i>TFE3, TFEB</i>, or <i>MITF</i> gene fusions that are not responsive to standard treatments for RCC. 30061365 2018
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney
0.100 GeneticVariation disease BEFREE As cytology smears can be useful adjuncts in cytogenetic and molecular testing, we demonstrate TFE3 rearrangement by FISH analysis on cytologic smears in melanotic Xp11 translocation renal cancer. 29722173 2018
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney
0.100 GeneticVariation disease BEFREE The first is a melanotic TFE3 translocation renal cancer with an indolent clinical course, occurring in a patient more than 3-decades older than the usual average age in which such tumors have been described. 28969862 2017
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney
0.100 GeneticVariation disease BEFREE The corresponding mesenchymal neoplasms, including Xp11 neoplasm with melanocytic differentiation, TFE3 rearrangement-associated perivascular epithelioid cell tumor (PEComa) and melanotic Xp11 translocation renal cancer, can also harbor the identical gene fusion. 28315422 2017
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney
0.100 GeneticVariation disease BEFREE In summary, we describe here for the first time the miRNA expression profiles of a molecularly distinct type of renal cancer associated with Xp11.2 translocations involving the TFE3 gene. 28411178 2017
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney
0.100 GeneticVariation disease BEFREE Recently, an increasing number of TFE3 rearrangement-associated tumours have been reported, such as TFE3 rearrangement-associated perivascular epithelioid cell tumours (PEComas), melanotic Xp11 translocation renal cancers and melanotic Xp11 neoplasms. 26844676 2016
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney
0.100 GeneticVariation disease BEFREE We examined 12 such cases, including 5 TFE3 rearrangement-associated PEComas located in the pancreas, cervix, or pelvis and 7 melanotic Xp11 translocation renal cancers, using clinicopathologic, immunohistochemical, and molecular analyses. 26274027 2015
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney
0.100 Biomarker disease BEFREE Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers. 25048860 2014
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney
0.100 Biomarker disease BEFREE We assessed the utility of break-apart fluorescence in situ hybridization (FISH) in establishing the diagnosis for suspected or unclassified cases with negative or equivocal TFE3 immunostaining by analyzing 24 renal cancers with break-apart TFE3 FISH and comparing the molecular findings with the results of TFE3 and cathepsin K immunostaining in the same tumors. 23598965 2013
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney
0.100 GeneticVariation disease BEFREE Sporadic, nonfamilial kidney cancer includes clear cell kidney cancer (75%), type 1 papillary kidney cancer (10%), papillary type 2 kidney cancer (including collecting duct and medullary RCC) (5%), the microphalmia-associated transcription (MiT) family translocation kidney cancers (TFE3, TFEB, and MITF), chromophobe kidney cancer (5%), and oncocytoma (5%). 23038766 2012
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney
0.100 GeneticVariation disease BEFREE The morphologic and immunohistochemical discrepancies between this intriguing melanotic tumor and other documented renal cell carcinomas bearing identical PSF-TFE3 gene fusion may suggest melanotic Xp11 translocation renal cancer is a distinct entity among the MiT/TFE family neoplasms. 19809274 2009
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney
0.100 Biomarker disease BEFREE A case of renal cancer with TFE3 gene fusion in an elderly man. Clinical, radiological and surgical findings. 17293662 2007