|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A novel RBMX-TFE3 gene fusion in a highly aggressive pediatric renal perivascular epithelioid cell tumor.
|
31408245 |
2019 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The PEComa-like tumor showed strong Melan-A and weak transcription factor E3 (TFE3) protein expression but no TFE3 gene rearrangement.
|
30876389 |
2019 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We are the first to report the results of molecular assays for the TFE3 gene rearrangement associated with gastric PEComa.
|
31141597 |
2019 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Despite cathepsin K, MITF and CD68 staining are known to be positive in a large number of PEComas and TFE3 rearrangement has been reported in a subset of PEComas, no data is available regarding the expression of these markers and the occurrence of TFE3 and TFEB rearrangement in clear cell "sugar" tumor of the lung.
|
29516164 |
2018 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Awareness of this morphologic pitfall and recognition of TFE3 gene-rearranged PEComa, as a distinct subtype of PEComa, is essential to avoid misdiagnosis.
|
29208563 |
2018 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Herein, we present a case of a TFE3-rearranged PEComa without the customary morphology that required ancillary investigation with TFE3 immunohistochemistry and break-apart fluorescence in situ hybridization for proper categorization.
|
29626599 |
2018 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The corresponding mesenchymal neoplasms, including Xp11 neoplasm with melanocytic differentiation, TFE3 rearrangement-associated perivascular epithelioid cell tumor (PEComa) and melanotic Xp11 translocation renal cancer, can also harbor the identical gene fusion.
|
28315422 |
2017 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor had morphologic features matching those of other previously described TFE3-translocated PEComas, including epithelioid morphology, diffuse and strong nuclear immunoreactivity for TFE3, and minimal staining with myoid markers.
|
27189222 |
2017 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
TFE3 also appeared to be overexpressed in 6 (21%) of 26 hepatic AMLs and 3 (100%) of 3 PEComas, but in none of the renal AMLs.
|
27865795 |
2017 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Here we describe a case of a melanotic PEComa with NONO-TFE3 fusion occurring in the sinonasal mucosa, as demonstrated by both next-generation sequencing and molecular cytogenetic studies.
|
28009605 |
2017 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
There are noted similarities between that entity and TFE3 associated PEComas.
|
28969862 |
2017 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A distinct subset of deep-seated PEComas has been shown to carry TFE3 fusions.
|
26385848 |
2016 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We also describe the first RCC with a DVL2-TFE3 gene fusion, in addition to an extrarenal pigmented PEComa with a NONO-TFE3 gene fusion.
|
26975036 |
2016 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Recently, an increasing number of TFE3 rearrangement-associated tumours have been reported, such as TFE3 rearrangement-associated perivascular epithelioid cell tumours (PEComas), melanotic Xp11 translocation renal cancers and melanotic Xp11 neoplasms.
|
26844676 |
2016 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Rheb/mTOR/p70s6k Cascade and TFE3 Expression in Conventional and Sclerosing PEComas of the Urinary Tract.
|
26258755 |
2016 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We examined 12 such cases, including 5 TFE3 rearrangement-associated PEComas located in the pancreas, cervix, or pelvis and 7 melanotic Xp11 translocation renal cancers, using clinicopathologic, immunohistochemical, and molecular analyses.
|
26274027 |
2015 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results showed that TFE3-rearranged PEComas lacked coexisting TSC2 mutations, indicating alternative pathways of tumorigenesis.
|
25651471 |
2015 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
TFE3 translocation-associated perivascular epithelioid cell neoplasm (PEComa) of the gynecologic tract: morphology, immunophenotype, differential diagnosis.
|
25517951 |
2015 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In summary, unusual cases of PEComa with TFE3 gene rearrangement might present malignant histological features and aggressive clinical behavior.
|
25239799 |
2014 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
All these clinicopathologic features are suggestive of TFE3-rearranged PEComas of the cervix.
|
25337301 |
2014 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This report adds to the known data regarding urinary bladder PEComas and PEComas with TFE3 rearrangement, indicating that both can pursue an aggressive course.
|
23797724 |
2013 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We report, for the first time, a unique case of TFE3-positive PEComa presenting as acute appendicitis in a 24-year-old woman.
|
23451753 |
2013 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We immunohistochemically analysed 17 cases of primary cutaneous PEComas for TFE3, and five of them also for SOX-10, and also analysed them by FISH for TFE3 rearrangement.
|
23711163 |
2013 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This is the first reported case of renal eAML/PEComa with a TFE3 gene break, and it has unique histological findings as compared to previously reported TFE3 gene fusion-positive PEComas.
|
23224603 |
2012 |
|
Perivascular Epithelioid Cell Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
None of the other 24 PEComas (mean patient age 54 y) showed TFE3 gene alterations, though 4 exhibited moderate positive (2+) TFE3 immunoreactivity.
|
20871214 |
2010 |