TFRC, transferrin receptor, 7037

N. diseases: 359; N. variants: 40
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.340 AlteredExpression disease BEFREE <b>Results:</b> TfR1 expression was higher in CRC tissues than in normal tissues (57.2% vs 22.9%, <i>P</i><0.001). 31372038 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.340 AlteredExpression disease BEFREE Significant differences were observed in the expression of 44 of these proteins, including ITGA5, GPRC5A, PDGFRB, and TFRC, which have already been shown to be overexpressed in colorectal cancer, as well as proteins with unknown function, such as C8orf55. 24687888 2014
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.340 Biomarker disease CTD_human In this case high expression of TfR1 was found in colorectal carcinoma samples of Dukes A or B grade, and well differentiated colorectal carcinoma cells. 16111806 2006
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.340 GeneticVariation disease BEFREE Whereas a recent study reported an increased risk of colorectal cancer associated with any HFE germ line mutation (C282Y or H63D), other investigators have concluded there is no increased risk, or that any increase is dependent on polymorphisms in HFE-interacting genes such as the transferrin receptor (TFR). 15941956 2005
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.340 GeneticVariation disease BEFREE In previous studies we found an interaction between HFE and TFR genotypes in multiple myeloma and breast and colorectal carcinomas. 11096344 2000