Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease BEFREE TGF-β1/TβRII/Smad3 signaling pathway promotes VEGF expression in oral squamous cell carcinoma tumor-associated macrophages. 29462614 2018
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease BEFREE Conversely, increased TGF-β1 and activated TGF-βRI and Smad3 have all been shown to have tumor-promoting effects in experimental systems of human and mouse SCCs. 29206939 2018
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE Immunohistochemical Study of TGF-β1 in Oral Leukoplakia and Oral Squamous Cell Carcinoma: Correlations Between Clinicopathologic Factors and Overall Survival. 26990749 2017
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE To investigate the role of TGF-β1 on epithelial mesenchymal transition (EMT) and invasion in oral squamous cell carcinoma cell line Tca8113. 28537671 2017
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease BEFREE Nintedanib dose-dependently inhibited the TGF-β1-induced expression of a panel of pro-fibrotic activation markers in both ADC-TAFs and control fibroblasts derived from uninvolved lung parenchyma, whereas such inhibition was very modest in SCC-TAFs. 28898237 2017
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease BEFREE Moreover, the expression of TGF‑β1 and SMAD4 proteins was elevated in cervical squamous carcinoma and cervical adenocarcinoma tissues. 27748903 2016
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease BEFREE Immunohistochemical Expression of CD105 and TGF-β1 in Oral Squamous Cell Carcinoma and Adjacent Apparently Normal Oral Mucosa and its Correlation With Clinicopathologic Features. 25710582 2016
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease BEFREE Pattern of TGFbeta receptor 1 expression differs between kras-mutated keratoacanthomas and squamous cell carcinomas of the skin. 24954139 2014
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE We incubated the p16-positive CERV196 and p16-negative HNSCC22B SCC cell lines with EGF and EGF/TGFβ1 (10 ng/ml) and detected E-cadherin, vimentin and β-catenin by immunocytochemistry and enzyme-linked immunosorbent assay after 5, 24 and 96 h. 25503133 2014
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE The transforming growth factor beta-1 (TGFβ-1 -509 C/T) polymorphism was inversely associated with having an oral SCCA among persons homozygous for the recessive variant (ORcrude = 0.27; 95% CI 0.09-0.79). 24278120 2013
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease BEFREE TGF-β1 protein and its receptor I (TGF-βR1) were overexpressed in urine samples in malignant group compared with chronic cystitis and in SQCC group compared with TCC group. 21429769 2013
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE Our data suggest that NK cells in NSCLC act as proangiogenic cells, particularly evident for SCC and in part mediated by TGFβ(1). 23441128 2013
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease CTD_human Use of a TGFbeta type I receptor inhibitor in mouse skin carcinogenesis reveals a dual role for TGFbeta signaling in tumor promotion and progression. 20852150 2010
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE Association between transforming growth factor beta1 genetic polymorphism and response to chemoradiotherapy in head and neck squamous cell cancer. 19260117 2009
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE Growth inhibition induced by transforming growth factor-beta1 in human oral squamous cell carcinoma. 18418730 2009
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease LHGDN Inhibition of TGF-beta1 suppresses motility and invasiveness of oral squamous cell carcinoma cell lines via modulation of integrins and down-regulation of matrix-metalloproteinases. 19082463 2009
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease LHGDN The expression levels of TGF-beta1 and its type I and type II receptors (TbetaRI and TbetaRII) were assessed by immunohistochemical and Western blot analyses in 22 oral squamous cell carcinoma lesions, in their normal adjacent mucosa and in the squamous carcinoma cell lines FaDu and CAL27. 18202754 2008
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease BEFREE Because transforming growth factor beta1 (TGF-beta1) is up-regulated in OSCC tumors, we examined the relationship between TGF-beta1 signaling and MMP-9 in human OSCC specimens. 18234959 2008
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease LHGDN TGFB1 and TGFBR2 functional polymorphisms and risk of esophageal squamous cell carcinoma: a case-control analysis in a Chinese population. 17680270 2008
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease LHGDN Genetic variation in transforming growth factor-beta1 gene associated with increased risk of esophageal squamous cell carcinoma. 17990985 2007
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE A study in this issue of Cancer Cell shows that mice with a targeted knockout of the type II TGFbeta receptor in stratified epithelia specifically develop spontaneous squamous cell carcinomas in the anogenital region, but not in the skin. 17936552 2007
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease LHGDN Aberrant expression of Smad4, a TGF-beta signaling molecule, in oral squamous cell carcinoma. 17023741 2006
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease LHGDN Loss of p12CDK2-AP1 expression in human oral squamous cell carcinoma with disrupted transforming growth factor-beta-Smad signaling pathway. 17217620 2006
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease LHGDN Increased expression of c-Ski as a co-repressor in transforming growth factor-beta signaling correlates with progression of esophageal squamous cell carcinoma. 14712482 2004
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease LHGDN Matrix metalloproteinases and TGFbeta1 modulate oral tumor cell matrix. 15033492 2004