TGFB1, transforming growth factor beta 1, 7040

N. diseases: 1558; N. variants: 50
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 GeneticVariation disease BEFREE The data showed that PCFL was significantly increased in hearts of mice subjected to MI and CFs treated with transforming growth factor-β1 (TGF-β1). 31220469 2019
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 Biomarker disease BEFREE In conclusion, TGF-β1 may impede the full benefit of corrector/potentiator therapy in CF patients. 31590401 2019
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 AlteredExpression disease BEFREE Pulmonary TGFβ1 expression was sufficient to produce pulmonary remodeling and abnormalities in lung mechanics that were associated with both shared and unique cell signaling pathway activation in CF and non-CF mice. 29877096 2018
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 Biomarker disease BEFREE The present results demonstrated that osthole could inhibit the collagen I and III expressions and their ratio in CFs treated with TGF-β1 via Smad signaling pathway, which might be one of its anti-fibrotic action mechanisms. 27870967 2017
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 Biomarker disease BEFREE Additionally, it was demonstrated that cell population of CFs treated with NRG in the S-phase became smaller whereas that of CFs in the G0/G1-phase increased when compared with the TGF-β1 group. 29104653 2017
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 Biomarker disease BEFREE Therefore, we propose that TGF-β1-induced mucociliary dysfunction in CF airways is associated with BK inactivation related to a LRRC26 decrease and is amenable to treatment with clinically useful TGF-β1 inhibitors. 26338706 2015
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 GeneticVariation disease BEFREE On the basis of our results, the -509C/T polymorphism of the TGFB1 gene seems to be a modulator factor of cystic fibrosis. 26277914 2015
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 Biomarker disease BEFREE The cytokine TGF-β1 is frequently elevated in CF patients. 23671668 2013
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 Biomarker disease BEFREE TGF β 1 in IS (CF/controls median 76.5/59.1 pg/mL, P < 0.074) was higher in CF. 24062613 2013
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 Biomarker disease BEFREE On 19q13, TGFB1 and the cystic fibrosis modifier 1 locus (CFM1) have been identified as modifiers of the course of the monogenic disease cystic fibrosis (CF). 20047061 2010
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 GeneticVariation disease BEFREE Association of MBL2, TGF-beta1 and CD14 gene polymorphisms with lung disease severity in cystic fibrosis. 19466271 2009
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 Biomarker disease BEFREE To assess whether any of 9 polymorphisms in 5 candidate genes (alpha(1)-antitrypsin or alpha(1)-antiprotease [SERPINA1], angiotensin-converting enzyme [ACE], glutathione S-transferase [GSTP1], mannose-binding lectin 2 [MBL2], and transforming growth factor beta1 [TGFB1]) are associated with severe liver disease in patients with CF. 19738092 2009
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 Biomarker disease BEFREE These results demonstrate that TGFB1 is a modifier of CF lung disease and reveal a previously unrecognized beneficial effect of TGFB1 variants upon the pulmonary phenotype. 18424453 2008
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 Biomarker disease BEFREE In this issue of the JCI, Dorfman et al. demonstrate in a large, population-based study that two previously studied modifier genes, coding for mannose-binding lectin 2 and TGF-beta1, influence pulmonary outcome in pediatric CF patients (see the related article beginning on page 1040). 18292812 2008
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 GermlineModifyingMutation disease ORPHANET These results demonstrate that TGFB1 is a modifier of CF lung disease and reveal a previously unrecognized beneficial effect of TGFB1 variants upon the pulmonary phenotype. 18424453 2008
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 GeneticVariation disease BEFREE These findings support the concept that TGFB1 gene variants appear to be important genetic modifiers of lung disease progression in CF. 19009622 2008
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 Biomarker disease BEFREE In conclusion, the role of TGFbeta1 as a CF modulator, suggested from studies with a case-control setting, needs to be interpreted with caution unless family-based analysis is carried out to identify parental genetic and non-genetic effects. 17406643 2007
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 Biomarker disease LHGDN In CF, both extremes, highest or lowest TGF-beta 1 production, were associated with impaired lung function. 17052957 2006
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 GeneticVariation disease BEFREE We did not prove the association of TGF-beta1 polymorphisms and lung function in CF, however, the TT (codon 10)/GG (codon 25) genotype was preferentially associated with CF-related liver disease and diabetes. 17052957 2006
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 GeneticVariation disease LHGDN Genetic modifiers of lung disease in cystic fibrosis. 16207846 2005
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 AlteredExpression disease LHGDN The role of hepatic stellate cells and transforming growth factor-beta(1) in cystic fibrosis liver disease. 12000722 2002
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 AlteredExpression disease BEFREE We conclude that a CF-related reduction in Smad3 protein expression selectively alters TGF- beta1-mediated signaling in CF epithelium, potentially contributing to aggressive inflammatory responses. 11726399 2001
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 GeneticVariation disease BEFREE TGF-beta(1) genotypes may have a role in mediating pulmonary dysfunction in patients with cystic fibrosis. 10817792 2000
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 Biomarker disease GENOMICS_ENGLAND
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis
0.700 Biomarker disease CTD_human