Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
In summary, PD29 reversed EMT and transformation of fibroblasts into myofibroblasts <i>in vitro</i> and prevented PF <i>in vivo</i> possibly by suppressing the TGF-β1/Smad pathway.
|
31210057 |
2020 |
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Here, we found that LSD1 expression was elevated in lung tissues of mice with bleomycin-induced pulmonary fibrosis and lung fibroblasts treated with transforming growth factor-β1 (TGF-β1).
|
31830521 |
2020 |
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Tanshinone IIA attenuates silica-induced pulmonary fibrosis via inhibition of TGF-β1-Smad signaling pathway.
|
31706104 |
2020 |
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
GHK-Cu presented a protective effect in BLM-induced inflammation and oxidative stress by inhibiting EMT progression and suppressing TGFβ1/Smad2/3 signalling in pulmonary fibrosis.
|
31809714 |
2020 |
Pulmonary Fibrosis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In vivo, PM exposure markedly elevated the levels of inflammatory cytokines and TGF-β1 in BALF, induced lung fibrosis.
|
31295660 |
2019 |
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
The in vitro cells model, cells were incubated with recombinant human TGF-β1 for 24 h to get TGF-β<sub>1</sub>-induced pulmonary fibrosis.
|
30709583 |
2019 |
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
These results indicated that pirfenidone intervention inhibited the epithelial-mesenchymal transition and pulmonary fibrosis in rat silicosis model, which effects may be related to the TGF-β1/smad pathway.
|
30394303 |
2019 |
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Together, these results suggest that activation of AMPK by WEL followed by reduction in TGFβ1/Raf-MAPK signaling pathways may have a therapeutic potential in pulmonary fibrosis.
|
30890932 |
2019 |
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
The increase of miR-140 inhibited TGF-β1-induced pulmonary fibrosis, and H19 upregulation diminished the inhibitory effects of miR-140 on TGF-β1-induced pulmonary fibrosis, which was involved in the TGF-β/Smad3 pathway.
|
30988156 |
2019 |
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Transforming growth factor beta 1 (TGF-β1) plays a critical role in many pathological processes that characterize pulmonary fibrosis.
|
31586469 |
2019 |
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Baccatin III ameliorates bleomycin-induced pulmonary fibrosis via suppression of TGF-β1 production and TGF-β1-induced fibroblast differentiation.
|
31229901 |
2019 |
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Taken together, the miR-448-5p/TGF-β1/Six1 link may play roles in the progression of EMT and pulmonary fibrosis in asthma.
|
30362537 |
2019 |
Pulmonary Fibrosis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our study demonstrated that SIRT6 inhibited MWCNTs-induced EMT in BEAS-2B cells through TGF-β1/Smad2 signaling pathway, which depended on its deacetylase activity, and provided evidences that targeting SIRT6 could be a potential novel therapeutic strategy for MWCNTs-induced pulmonary fibrosis.
|
31005557 |
2019 |
Pulmonary Fibrosis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We investigate the effect of XJXBCQ against PF and its mechanism via the regulation of TGF-β1/Smad in vitro and in vivo.
|
31695321 |
2019 |
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Studies have shown that transforming growth factor-β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) functions as a central mediating process that contributes to PF.
|
31105865 |
2019 |
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Therefore, TRB3 may promote the formation of PF through the TGF‑β1/Smad3 signaling pathway.
|
30720074 |
2019 |
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
The present study investigated the role of Nimbolide, an important active constituent of Neem in TGF-β1 induced in vitro and bleomycin induced in vivo model of pulmonary fibrosis, with a slight emphasis on regulation of fibrosis related autophagy.
|
31377591 |
2019 |
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Here, we aimed to investigate the chemical constituents and biological activities of Hypericum longistylum and detect whether the isolated compounds inhibit the TGF-β1/Smad3 signaling pathway to identify candidate compounds for the treatment of pulmonary fibrosis.
|
31606345 |
2019 |
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
To assess the in vivo role of P311 in lung fibrosis, BLM was instilled into the lungs of P311-knockout mice, in which fibrotic changes were significantly decreased in tandem with a reduction in TGF-β1, -β2, and -β3 concentration/activity compared with BLM-treated wild-type mice.
|
30230348 |
2019 |
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
This study evaluated the role of TGF-β1 in HFD-induced AHR and lung fibrosis in a murine model.
|
31133649 |
2019 |
Pulmonary Fibrosis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, WT mice receiving adoptive macrophages from TIM-3-TG mice also had more serious lung fibrosis and increased expression of TGF-β1 and IL-10 than those receiving macrophages from WT mice.
|
31162951 |
2019 |
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Surfactant dysfunction and alveolar collapse are linked with fibrotic septal wall remodeling in the TGF-β1-induced mouse model of pulmonary fibrosis.
|
30700849 |
2019 |
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Neutralization of IL-18 by IL-18BP improved the survival rate and ameliorated BLM-induced PF in mice, which was associated with attenuated pathological changes, reduced collagen deposition, and decreased content of transforming growth factor-β1 (TGF-β1).
|
30527805 |
2019 |
Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Bleomycin (BLM)-induced PF in Nrf2-knockout (Nrf2<sup>-/-</sup> ) and wild-type (WT) mice and transforming growth factor β1 (TGF-β1)-induced EMT in rat type II alveolar epithelial cell line (RLE-6TN) and human alveolar epithelial cell line (A549) were established to observe the relationship among Nrf2, HMGB1, and EMT by western blot and immunohistochemistry.
|
30370641 |
2019 |
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Altogether, our results identified TGFβ1 as an APA regulator through NUDT21 depletion amplifying pulmonary fibrosis.
|
31488543 |
2019 |