TH, tyrosine hydroxylase, 7054

N. diseases: 321; N. variants: 71
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.320 Biomarker disease PSYGENET The results indicate that there exists possible interrelation between TH and TPH gene expression and epigenetic histone acetylation in CUS-induced depressive rats, which at least partly contributes to the etiology of depression. 24495952 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.320 Biomarker disease PSYGENET Tyrosine-hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) mRNA levels were decreased both in right and left atria, while phenylethanolamine N-methyltransferase (PNMT) mRNAs were increased in left atria and both ventricles of depression model rats. 23305027 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.320 Biomarker disease PSYGENET We found that genotype Met/Met of the Val66Met polymorphism of the brain-derived neurotrophic factor gene was positively associated with depressive disorder (P < 0.05), but we were not able to find any significant associations of both the depressive disorder and metabolic syndrome with the remaining polymorphisms studied (methylenetetrahydrofolate reductase 677CT, methylenetet rahydrofolate reductase 1298AC, endothelial nitric oxide synthase Glu298Asp, and tyrosine hydroxylase). 20163778 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.320 GeneticVariation disease BEFREE We found that genotype Met/Met of the Val66Met polymorphism of the brain-derived neurotrophic factor gene was positively associated with depressive disorder (P < 0.05), but we were not able to find any significant associations of both the depressive disorder and metabolic syndrome with the remaining polymorphisms studied (methylenetetrahydrofolate reductase 677CT, methylenetet rahydrofolate reductase 1298AC, endothelial nitric oxide synthase Glu298Asp, and tyrosine hydroxylase). 20163778 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.320 Biomarker disease PSYGENET Elevated renal norepinephrine in proANP gene-disrupted mice is associated with increased tyrosine hydroxylase expression in sympathetic ganglia. 17482290 2007
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.320 Biomarker disease PSYGENET Overexpressed thioredoxin compensates Fanconi anemia related chromosomal instability. 11948424 2002
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.320 GeneticVariation disease BEFREE To determine whether the genetic polymorphisms of the tyrosine hydroxylase ([TH] HUMTH01) and insulin (INS-VNTR) genes contribute to insulin resistance in depressive illness, we analyzed the association between the polymorphisms and insulin resistance in 41 Japanese patients with depressive disorder, 204 normal control subjects, 161 cohort subjects with normal glucose tolerance (NGT) and without depressive symptomatology, and 59 NGT subjects with depressive symptomatology. 11016895 2000