Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.400 AlteredExpression disease BEFREE Whereas TH levels were correlated with ERK5 levels in normal adrenal medullas, ERK5 was down-regulated and TH was up-regulated in pheochromocytomas, indicating that TH levels are regulated by alternative mechanisms in tumors. 26739108 2016
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.400 AlteredExpression disease BEFREE We observed an increase of TH mRNA concentration without correlation with TH protein expression in primary cell culture of PHEO and PGL incubated with dexamethasone during 24 hours; no changes were monitored for PNMT and DBH at both mRNA and protein level in PHEO and PGL. 25946206 2016
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.400 Biomarker disease CTD_human At both the protein and mRNA levels, MAOA and COMT are detected less often in PHEO compared with adrenal medulla, conversely to tyrosine hydroxylase, L-amino acid decarboxylase, and dopamine β-hydroxylase, much more expressed in tumor tissue. 22569243 2012
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.400 AlteredExpression disease BEFREE The above differences in clinical presentation were largely explained by lower total tissue contents of catecholamines and expression of TH and negligible stores of epinephrine and expression of PNMT in pheochromocytomas from VHL than from MEN 2 patients. 11344198 2001
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.400 Biomarker disease BEFREE We measured the concentrations of mRNA coding for the catecholamine-synthesizing enzymes tyrosine hydroxylase, aromatic L-amino acid decarboxylase (AADC), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyl transferase (PNMT) and for the catecholamine contents in 12 pheochromocytomas and 12 normal adrenal medullas. 9578504 1998
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.400 AlteredExpression disease BEFREE Tyrosine hydroxylase gene expression in varying forms of human pheochromocytoma. 8913331 1996
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.400 Biomarker disease BEFREE We show that the diversity of TH mRNAs is greater than previously described in the autonomous nervous system: New splice junctions corresponding to the skipping of exon 3 were identified by amplification of cDNA synthesized from pheochromocytoma RNA. 8666991 1996
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.400 AlteredExpression disease BEFREE Such assays demonstrated that a region between -503 and -578 contributed to rat TH promoter activity in the pheochromocytoma cell line PC12. 7908942 1994
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.400 Biomarker disease BEFREE Purification and characterization of the blue-green rat phaeochromocytoma (PC12) tyrosine hydroxylase with a dopamine-Fe(III) complex. Reversal of the endogenous feedback inhibition by phosphorylation of serine-40. 1352446 1992
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.400 Biomarker disease BEFREE In most nonexpressing cell lines, CAT levels were less than 5% of that found in a TH-positive pheochromocytoma line (PC8b). 2571679 1989
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.400 AlteredExpression disease BEFREE Lambda gt 11 cDNA library constructed from human pheochromocytoma was screened with a synthetic 23-mer oligonucleotide complementary to rat TH mRNA. 2887169 1987
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.400 Biomarker disease BEFREE In vitro translation of human pheochromocytoma messenger RNAs: characterization of tyrosine-hydroxylase and dopamine-beta-hydroxylase. 2864960 1985