Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
After first determining neurite elongation and expression levels of tyrosine hydroxylase and high size neurofilament as useful differentiation markers, we observed that TSA increased neuroblastoma cell differentiation, while sirtinol had the antagonistic effect of decreasing it.
|
29516351 |
2018 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
High levels of bone marrow TH and PHOX2B and of peripheral blood PHOX2B at diagnosis allow early identification of a group of high-risk infant and toddlers with neuroblastoma who may be candidates for alternative treatments.
|
29603574 |
2018 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In a tyrosine hydroxylase MYCN (TH-MYCN) neuroblastoma mouse model, immunohistochemical staining revealed strong nuclear TRIM16 expression in differentiating ganglia cells but not in the tumor-initiating cells.
|
23422002 |
2013 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Molecular detection of tyrosine hydroxylase in the peripheral blood of patients with neuroblastoma: useful at diagnosis but not predictive of subsequent relapse during off-therapy follow-up.
|
21083359 |
2011 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's disease.
|
21951066 |
2011 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of tyrosine hydroxylase increases the resistance of human neuroblastoma cells to oxidative insults.
|
19815691 |
2010 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We used embryonal carcinoma (EC) and neuroblastoma (NB) cell lines and found that lovastatin promoted apoptosis and induced expression of the neuronal differentiation markers, tyrosine hydroxylase (TH), and growth-associated protein 43.
|
20694854 |
2010 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human neuroblastoma cells transfected with tyrosine hydroxylase gain increased resistance to methylmercury-induced cell death.
|
20650311 |
2010 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Measurement of tyrosine hydroxylase transcripts in bone marrow using biopsied tissue instead of aspirates for neuroblastoma.
|
20582938 |
2010 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tyrosine hydroxylase and 3,4-dihydroxyphenylalanine (dopa) decarboxylase transcripts were demonstrated in 10 of 13 cases of neuroblastoma.
|
20231617 |
2010 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Analysis in an inducible neuroblastoma cell culture model demonstrated altered tyrosine hydroxylase activity in the presence of the mutant but not wildtype torsinA protein.
|
19761814 |
2009 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We investigated whether detection of minimal residual disease (MRD) in peripheral blood stem cells (PBSC) by using tyrosine hydroxylase (TH) expression could predict outcome of patients with advanced neuroblastoma.
|
19125082 |
2009 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a.
|
19285077 |
2009 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The depletion of CD8(+)T cells completely abrogated the hTH vaccine-mediated anti-NB immune response.
|
19671753 |
2009 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The tyrosine hydroxylase (TH) promoter-driven TH-MYCN transgenic mouse model faithfully recapitulates many hallmarks of human MYCN-amplified neuroblastoma.
|
19147568 |
2009 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tyrosine hydroxylase (TH), dopa decarboxylase (DDC) and GD2 synthase (GD2S) mRNAs were analyzed in 554 blood (PB) and bone marrow (BM) samples from 58 children with neuroblastoma.
|
18814238 |
2008 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression of the human MYCN oncogene driven by a tyrosine hydroxylase promoter causes tumours in transgenic mice that recapitulate the childhood cancer neuroblastoma.
|
17449239 |
2007 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
RT-PCR analysis of compounds of catecholamine metabolism (in particular tyrosine hydroxylase, TH) is widely used for the detection of contaminating neuroblastoma cells in hematopoietic stem cell preparations.
|
16827147 |
2006 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expressed recombinant PTD-TH with a molecular weight of 61 kD was successfully transduced (1 microM) into the dopaminergic SH-sy5y human neuroblastoma cells in vitro and visualized by immunohistochemical assay.
|
16762325 |
2006 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Seven NB cell lines and 30 bone marrow (BM) samples from patients with high-risk NB were analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR) for MYCN expression, and for the established NB marker tyrosine hydroxylase.
|
17023822 |
2006 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report that phosphatidylinositol 3-kinase (PI3K) inhibition in murine neuroblastoma (driven by a tyrosine hydroxylase-MYCN transgene) led to decreased tumor mass and decreased levels of Mycn protein without affecting levels of MYCN mRNA.
|
16912192 |
2006 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We examined effects of the selective norepinephrine-transporter (NET) inhibitor antidepressant desipramine (DMI) on expression of TH in human neuroblastoma cells (SK-N-BE[2]M17) and in rat brain regions.
|
15710233 |
2005 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Based on these results, the detection of TH mRNA is very useful both as a tumor marker for NB and for detecting minimal residual disease.
|
14993794 |
2004 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We demonstrate the induction of protective immunity against syngeneic murine NXS2 neuroblastoma in A/J mice following vaccination with tyrosine hydroxylase (TH)-derived antigens.
|
15650237 |
2004 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, THp was chosen for a neuroblastoma-selective suicide gene therapy approach using the herpes simplex virus type 1 thymidine kinase (HSV-tk)/ganciclovir (GCV) system.
|
15181182 |
2004 |