|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The results of this meta-analysis suggest that the rs4986790 and rs4986791 polymorphisms in toll like receptor 4 gene may have no statistically significant influence on sepsis susceptibility.
|
27958344 |
2016 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
During hemorrhagic shock and sepsis, inflammation triggers the translocation of CIRP from the nucleus to the cytosol and its release to the extracellular space. eCIRP then induces inflammatory responses in macrophages, neutrophils, lymphocytes, and dendritic cells. eCIRP also induces endoplasmic reticulum stress and pyroptosis in endothelial cells by activating the NF-κB and inflammasome pathways, and necroptosis in macrophages via mitochondrial DNA damage. eCIRP works through the TLR4-MD2 receptors.
|
30645013 |
2019 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results indicate that TFAM repairs mtDNA by blocking the TLR4/ROS/P38MAPK signaling pathway in inflammatory cells, thereby repairing septic tubular epithelial cells, and TFAM may serve as a new target for sepsis therapy.
|
31430762 |
2019 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Toll-like receptor 4 (TLR4)-a transmembrane pattern-recognition receptor responsible for propagating the immediate immune response to Gram-negative bacterial infection-plays a central role in the pathogenesis of sepsis and chronic inflammation-related disorders.
|
30276970 |
2018 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Candidate single nucleotide polymorphisms (SNPs) within bacterial recognition (TLR4 +896, CD14 -159) and inflammatory response (TNF-alpha -308, IL-1beta -31, IL-6 -174) loci were evaluated for association with increased risk for severe sepsis (sepsis plus organ dysfunction or septic shock) and mortality.
|
15520404 |
2004 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Consequently, this study was not able to detect associations between TLR4 polymorphisms and sepsis in this population.
|
23871732 |
2013 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The IL-1 receptor-associated kinase (IRAK-1) plays a central role in TLR2- and TLR4-induced activation of nuclear factor (NF)-kappaB, a critical event in the transcriptional regulation of many sepsis-associated proinflammatory mediators.
|
16528020 |
2006 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Collectively, the results from the current study demonstrate CD16 as a key regulator of the TRIF-dependent TLR4 pathway in human monocytes and their CD16-expressing subset, with implications in sepsis.
|
22427642 |
2012 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Adjusting for independent risk factors, carriage of the variant TLR4 896 G allele was associated with decreased risk of complicated sepsis (odds ratio = 0.3, 95% confidence interval, 0.1-0.7, p = 0.008).
|
19131814 |
2009 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Sch B could increase miR-17-5p expression, promote inflammation, and decrease TLR4 expression in sepsis mice and LPS-induced macrophages.
|
30506107 |
2019 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Hyporesponsiveness by phagocytes is a well-known phenomenon in sepsis that is frequently induced by low-dose endotoxin stimulation of Toll-like receptor 4 (TLR4) but can also be found under sterile inflammatory conditions.
|
25497086 |
2014 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Myeloid differentiation 2 (MD2) is essential to the recognition of lipopolysaccharide (LPS) and the subsequent mediation of toll-like receptor 4 (TLR4)-dependent acute inflammatory disorders including sepsis and acute lung injury.
|
28858767 |
2017 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Dex pretreatment protects against LPS-induced ALI via inhibiting the activation of the TLR-4/NF-kB signaling pathway by upregulating the expression of Cav-1 downregulated by sepsis.
|
31545263 |
2019 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis.
|
28976923 |
2017 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Allicin Improves Lung Injury Induced by Sepsis via Regulation of the Toll-Like Receptor 4 (TLR4)/Myeloid Differentiation Primary Response 88 (MYD88)/Nuclear Factor kappa B (NF-κB) Pathway.
|
30957795 |
2019 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The toll-like receptor 4/2242 polymorphism is a functional variant and might be used as a relevant risk estimate for organ dysfunction and sepsis in trauma patients.
|
20228685 |
2010 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Candidate genes for asthma and allergic diseases co-associated with sepsis including innate immunity receptors and related molecules (CD14, TLR4 and AOAH) and novel genes such as MYLK provide good examples of pleitropic effects of innate immunity genes, where variants conferring risk to specific traits (i.e. sepsis) under one set of genetic and environmental circumstances confer a reduced risk in a different (but possibly related) clinical outcome (i.e. allergic asthma), and support the 'common variant/multiple disease' hypothesis.
|
17989521 |
2007 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Here we study the transcriptional patterns of tlr4 and of its modulator grp78 during human sepsis, and establish their correlations with the outcome of patients.
|
31314904 |
2019 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis.
|
12404174 |
2002 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
TLR4 recognizes lipopolysaccharide (LPS) and drives the secretion of inflammatory cytokines, often contributing to sepsis.
|
29343440 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Circulating histones contribute to inflammation, and to lethality in sepsis, a hyperinflammatory condition, by interacting with specific receptors, notably toll-like receptor 4 (TLR4).
|
29997623 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Transfer of a normal microbiota into antibiotic-treated neonates induced IL-17 production by group 3 innate lymphoid cells (ILCs) in the intestine, increasing plasma G-CSF levels and neutrophil numbers in a Toll-like receptor 4 (TLR4)- and myeloid differentiation factor 88 (MyD88)-dependent manner and restored IL-17-dependent resistance to sepsis.
|
24747744 |
2014 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aim of the present work was to delineate the beneficial role of BZL during sepsis, analyzing its effects on the cellular redox status and the possible link to the innate immunity receptor TLR4.
|
27899278 |
2017 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We conclude that TLR4 stimulation and human sepsis activate pathways that couple NAD(+) and its sensor SIRT1 with epigenetic reprogramming.
|
21245135 |
2011 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
These data indicate that HMGB1 accumulates in renal tissue and enters the urine and the interaction between HMGB1 and TLR4 turns TECs into inflammatory promoters during sepsis.
|
26312770 |
2016 |