|
Opioid abuse
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, TLR4 antagonists lacked reinforcer selectivity in reducing opioid self-administration and were not uniformly effective in a model of craving/relapse, suggesting limitations on the development of (+)-naltrexone or TLR4 antagonists as treatments for opioid abuse.
|
30741729 |
2020 |
|
Adenomatous Polyposis Coli
|
0.010 |
Biomarker
|
disease |
BEFREE |
After a series of validation experiments for the concerned genes, it was found that IL6, GM-CSF (CSF2), IL11, CCL3, S100A8 and S100A9 were significantly decreased in gut tumours of Apc<sup>Min/+</sup> TLR4<sup>-/-</sup> mice compared with Apc<sup>Min/+</sup> WT mice.
|
31650683 |
2020 |
|
polyps
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In this study, Apc<sup>Min/+</sup> intestinal adenoma mice were generated on TLR4-sufficient and TLR4-deficient backgrounds to investigate the carcinogenic effect of TLR4 in mouse gut by comparing mice survival, peripheral blood cells, bone marrow haematopoietic precursor cells and numbers of polyps in the guts of Apc<sup>Min/+</sup> WT and Apc<sup>Min/+</sup> TLR4<sup>-/-</sup> mice.
|
31650683 |
2020 |
|
Rheumatism
|
0.010 |
Biomarker
|
disease |
BEFREE |
LUM is associated with the pathogen-associated molecular pattern (PAMP) activation of the TLR4 signalling cascade, with TLR4 being highly associated with inflammation in rheumatic diseases.
|
31715293 |
2020 |
|
Mental deterioration
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We also found that the TREM2 R47H gene variant was associated with changes in cognitive decline in the large cohort of HD patients, whereas 2 of 3 TLR4 single nucleotide polymorphisms assessed were associated with changes in motor progression in this same group.
|
31724242 |
2020 |
|
Skin callus
|
0.010 |
Biomarker
|
disease |
BEFREE |
TLR4 knockout promoted fracture healing, reduced the number of osteoclasts, increased bone callus volume (BV) and callus mineralized volume fraction (BV/TV%) (P < 0.05), increased the maximum torque and torsional stiffness of callus (P < 0.05), reduced TNF-α, IL-1β and IL-6 expression (P < 0.01), and increased the expression levels of β-catenin, Wnt4, Wnt5B, PCNA and BMP-2 (P < 0.01).
|
31796334 |
2020 |
|
Hashimoto Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
TLR2 gene Arg677Trp, Arg753Gln, 196-174 del and TLR4 gene Asp299Gly, Thr399Ile polymorphism do not appear to have a role in the development of HT disease.
|
30924423 |
2020 |
|
Recurrent respiratory papillomatosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results demonstrate an abnormal TLR2 and TLR4 expression in mDCs may contribute to suppressive immune response to HPV6 or HPV11 infection and associated with disease activity in JORRP patients.
|
31726188 |
2020 |
|
Axial spondyloarthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Differential expression of TLR2 and TLR4 in α4β7-positive leukocytes of patients with axial spondyloarthritis.
|
31578573 |
2020 |
|
Periodontal inflammation
|
0.010 |
Biomarker
|
disease |
BEFREE |
MALAT1 enhances inflammatory cytokine production through sponging miR-20a and releasing TLR4, indicating a regulatory role of MALAT1 in periodontal inflammation.
|
31552681 |
2020 |
|
Overweight or obesity
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
A Carbohydrate Beverage Reduces Monocytes Expressing TLR4 in Children with Overweight or Obesity.
|
31825075 |
2020 |
|
Primary Myelofibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
EDA fibronectin-TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis.
|
30733282 |
2019 |
|
Fabry Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found increased TNF, interleukin (IL-)1β, and toll-like receptor 4 (TLR4) gene expression in FD men (p < .05 to p < .01).
|
31221509 |
2019 |
|
Bowen's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TLR4 expression was significantly higher in the SCC than in the AK or BD tissues.
|
31081044 |
2019 |
|
Brain Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
We further reveal that TLR2, but not TLR4, is essential for the tumor-triggered increase of MHC I in microglia. in vitro co-culture and in vivo experiments show that the glial TLR2-MHC I axis contributes to the proliferation and activation of CD8<sup>+</sup> T cells by brain tumor.
|
30720218 |
2019 |
|
Malignant neoplasm of skin
|
0.010 |
Biomarker
|
disease |
BEFREE |
TLR4 in skin cancer: From molecular mechanisms to clinical interventions.
|
31020719 |
2019 |
|
Merkel cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
TLR4 involvement has now been implicated in major types of skin malignancies, including nonmelanoma skin cancer, melanoma and Merkel cell carcinoma.
|
31020719 |
2019 |
|
Uterine Cervicitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
TLR4 and TLR9 polymorphisms, as well as haplotypes were shown to modulate the cervicitis risk.
|
31365550 |
2019 |
|
Eclampsia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of HIF-1a-mediated TLR4 activation decreases apoptosis and promotes angiogenesis of placental microvascular endothelial cells during severe pre-eclampsia pathogenesis.
|
31477211 |
2019 |
|
Flushing
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The results showed that IL-1β and IL-18 level in the flushing fluid was increased and TLR4, NLRP3, ASC, caspase-1, NF-κB and p-NF-κB expressions were up-regulated after the establishment of AGA rat model.
|
30697988 |
2019 |
|
Glaucoma, Open-Angle
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
TLR4 rs7037117 polymorphism had significant associations with increased risk of OAG in allelic model (OR=1.25; 95%CI: 1.09-1.44; P=0.002) and recessive model (OR=1.49; 95%CI: 1.08-2.04; P=0.01).
|
31428642 |
2019 |
|
Membranous glomerulonephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Down-regulation of the long non-coding RNA XIST ameliorates podocyte apoptosis in membranous nephropathy via the miR-217-TLR4 pathway.
|
30414341 |
2019 |
|
Intestinal Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Genetic deletion of TLR4, but not interleukin-1 receptor (IL-1R), in IMCs led to altered molecular profiles and reduction of intestinal tumors similar to the MyD88 deficiency.
|
30650348 |
2019 |
|
Jaundice, Obstructive
|
0.010 |
Biomarker
|
disease |
BEFREE |
Activation of the TLR4/TRAF6/NF-κB pathways was involved in the occurrence and development of intestinal mucosal injury and endotoxemia in mice with OJ.
|
31671112 |
2019 |
|
Actinic keratosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TLR4 expression was significantly higher in the SCC than in the AK or BD tissues.
|
31081044 |
2019 |