|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mice melanoma cells (B16F10) were treated with fenofibrate or LPS or LPS + fenofibrate or pre-treated with CLI-095 (a TLR4 inhibitor), followed by fenofibrate.
|
31175545 |
2020 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results indicate that pioglitazone, a PPARγ agonist, has a beneficial protective effect against melanoma via interfering with the TLR4-dependent signaling pathways.
|
31509504 |
2019 |
|
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, miR-145-5p overexpression inactivated the NF-κB pathway in melanoma in vitro and in vivo, which was reversed by TLR4 overexpression.
|
30701576 |
2019 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cancer cell-derived long pentraxin 3 (PTX3) promotes melanoma migration through a toll-like receptor 4 (TLR4)/NF-κB signaling pathway.
|
31253871 |
2019 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
TRIM44 activates the AKT/mTOR signal pathway to induce melanoma progression by stabilizing TLR4.
|
30922374 |
2019 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the relationship between TP and TLR4 in melanoma is not well explored.
|
29359608 |
2018 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, the possible impact of TLR4-dependent signaling pathway in PTX resistance in BCA and melanoma is proposed and using PTX in combination with CpdA may attenuate TLR4-mediated PTX resistance in the treatment of the patients.
|
29486738 |
2018 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Next, the role of TLR4 in cell proliferation and migration was assessed using the TLR4-positive (TLR4(+)) melanoma cell lines 501mel and 888mel, and TLR4-negative (TLR4(‒)) 928mel melanoma cells.
|
25175033 |
2014 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Immunohistological examination revealed the presence of enterovirus in pancreatic islet cells and exocrine tissues and hyperexpression of pattern recognition receptors (PRRs) including melanoma differentiation-associated antigen 5 (MDA5), retinoic acid-inducible gene-I (RIG-I), Toll-like receptor (TLR)3 and TLR4, essential sensors of innate immunity, in islet cells and mononuclear cells (MNCs) infiltrating islets.
|
23774118 |
2013 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
This patient had stage IV-M1c melanoma with documented progression during dacarbazine chemotherapy and received 5 TriMix-DC injections.
|
22159452 |
2012 |
|
melanoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Toll-like receptor 4 gene polymorphism influences dendritic cell in vitro function and clinical outcomes in vaccinated melanoma patients.
|
22552381 |
2012 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
|
22842228 |
2012 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
LHGDN |
Together, our results suggest that sHA in melanoma might promote tumor invasiveness by inducing MMP- and cytokine-expression, in part in a TLR4-dependent manner, providing new insights into the relationship between cancer and innate immunity.
|
18031543 |
2008 |
|
melanoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
By PCR array analysis, specific stimulation of TLR2, TLR3, and TLR4 on melanoma cells showed significant activation of the adaptor protein MyD88, as well as downstream signal transduction factors nuclear factor-kappaB and inflammatory response-related factors.
|
19001446 |
2008 |
|
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Melanoma cell lines are responsive in vitro to lipopolysaccharide and express TLR-4.
|
15922507 |
2006 |