Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Serum TLR4 protein levels of CAD patients showed no correlation with rs11536879 and rs11536889 polymorphisms.
|
31082501 |
2019 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Compared with those of the controls, the mRNA and protein expression of RFX1 were downregulated and the mRNA expression of TLR4 was upregulated in CD14<sup>+</sup> monocytes obtained from CAD patients and CD14<sup>+</sup> monocytes obtained from healthy controls treated with low-density lipoprotein (LDL).
|
30857550 |
2019 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study was to conduct a meta-analysis assessing the relationship between 2 common genetic variants in the TLR4 gene (rs4986790 and rs4986791) and susceptibility to CAD.
|
30784241 |
2019 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Receiver operating characteristic (ROC) analysis of 12 genes associated with toll-receptor signaling pathway in the 236 CAD patients from GEO database demonstrated that 12 genes expression could predict severe CAD with an area under the curve of 0.67, sensitivity of 77.65% and specificity of 51.52%.
|
30021655 |
2018 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
RESULTS TLR4 rs10116253 in the promoter region was associated with CAD risk.
|
28092654 |
2017 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Polymorphisms in the TLR4 gene may alter TLR4 expression and affect the extent and severity of coronary artery disease (CAD).
|
28002812 |
2017 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
HMGB1 and its 3 well-known receptors, receptor for advanced glycation end products, Toll-like receptor 2 (TLR2), and TLR4, were examined by immunohistochemistry on myocardial biopsy specimens from 18 elderly patients with CAD (10 with IRD, 8 without IRD).
|
28427050 |
2017 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association between Toll-like receptor 4 Asp299Gly polymorphism and coronary heart disease susceptibility.
|
28793055 |
2017 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interferon regulatory factor 2 (IRF2) and cell death‑inducing DFFA‑like effector b (CIDEB), which are regulated by signal transducer and activator of transcription 3 and myc‑associated factor X, were identified as common DEGs for CAD. miR‑455‑5p, miR‑455‑3p and miR‑1257, which are involved in the major histocompatibility complex (MHC)protein assembly pathway and peptide antigen assembly with MHC class I protein complex pathway, may regulate various miRNAs and target genes, including pro‑opiomelancortin (POMC), toll‑like receptor 4 (TLR4), interleukin 10 (IL10), activating transcription factor 6 (ATF6) and calreticulin (CALR).
|
26936111 |
2016 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The significant interaction between TLR4 rs11536889 and MyD88 rs7744 was associated with an increased CAD risk (p value for interaction = 0.024).
|
26959040 |
2016 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings suggested that EAT hypertrophy in CAD promotes adipocyte degeneration and drives local inflammation through increased infiltration of macrophages which are mainly polarized towards an M1 state and express both TLR-2 and TLR-4.
|
26841679 |
2016 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The microarray assay showed significant differences in seven TLR4-responsive miRNAs between the CAD and non-CAD groups (P<0.05).
|
25385173 |
2015 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No association between TLR2-Arg677Trp or TLR4-Asp299Gly and -Thr399Ile gene polymorphisms and the presence or the severity of CAD was observed.
|
25542811 |
2015 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
These single nucleotide polymorphisms explained 27.8% of variation in the CpG-oligonucleotide-induced IFN-α response and were also associated with Toll-like receptor-7/8- and Toll-like receptor-9-dependent IFN-α and IFN-β responses, but were not associated with inflammatory cytokine production in response to Toll-like receptor-4 stimulation or risk of coronary artery disease in 22,233 cases and 64,762 controls (odds ratio 1.00, 95% CI 0.98-1.02) using Mendelian randomization-based analyses.
|
25882064 |
2015 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The expression of TLR4 and TLR3 closely correlated with the severity of coronary artery disease as reflected by the number of coronary artery stenoses.
|
24146036 |
2014 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to determine whether let-7i is expressed with TLR4 in patients with CAD, and whether statins (atorvastatin or rosuvastatin) might affect these levels.
|
21899916 |
2012 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Levels of miR-146a/b, IRAK1 mRNA, TRAF6 mRNA and TLR4 mRNA/TLR4 protein were significantly higher in the CAD group than in the non-CAD group (all P<0.01).
|
20524934 |
2010 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Levels of miR-146a/b, IRAK1 mRNA, TRAF6 mRNA and TLR4 mRNA/TLR4 protein were significantly higher in the CAD group than in the non-CAD group (all P<0.01).
|
20524934 |
2010 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
TLR4 gene polymorphism (Asp299Gly) attenuates innate immune responsiveness, reduces the risk for coronary artery disease, and increases a chance of longevity.
|
19273219 |
2009 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
There was a significant linear association between the number of high-risk gene variants (IL6-174CC, SFTPD 11CC and TLR4 299AA) and the proportion of patients with coronary artery disease (P < 0.0005).
|
19140875 |
2009 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Association between Toll-like receptors and the extent and severity of coronary artery disease in patients with stable angina.
|
17172927 |
2007 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the TLR4 expression levels on peripheral blood monocytes in CAD patients were higher than those in non-CAD subjects and correlated with disease activity, even in low-hsCRP subjects.
|
17045300 |
2006 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We studied the TLR4 gene Asp299Gly polymorphism in relation to susceptibility to myocardial infarction in a cohort of patients with angiographically documented coronary artery disease, and performed a meta-analysis using data sets from three independent studies.
|
15864121 |
2005 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs inflammatory responses, is associated with reduced vascular inflammation (assessed by C-reactive protein [CRP]) and a decreased risk for CAD and diabetes.
|
15632890 |
2004 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The findings of this study do not support the hypothesis that the TLR4 Asp299Gly polymorphism influences predisposition to and progression of coronary artery disease.
|
12957699 |
2003 |