Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0520459
Disease: Necrotizing Enterocolitis
Necrotizing Enterocolitis
0.600 Biomarker disease BEFREE Toll-like receptor-4 in human and mouse colonic epithelium is developmentally regulated: a possible role in necrotizing enterocolitis. 25521917 2015
CUI: C0520459
Disease: Necrotizing Enterocolitis
Necrotizing Enterocolitis
0.600 Biomarker disease BEFREE Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis. 24519940 2014
CUI: C0520459
Disease: Necrotizing Enterocolitis
Necrotizing Enterocolitis
0.600 Biomarker disease BEFREE Our lead compound, C34, is a 2-acetamidopyranoside (MW 389) with the formula C17H27NO9, which inhibited TLR4 in enterocytes and macrophages in vitro, and reduced systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. 23776545 2014
CUI: C0520459
Disease: Necrotizing Enterocolitis
Necrotizing Enterocolitis
0.600 Biomarker disease BEFREE A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis. 23455503 2013
CUI: C0520459
Disease: Necrotizing Enterocolitis
Necrotizing Enterocolitis
0.600 Biomarker disease CTD_human Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling. 23650378 2013
CUI: C0520459
Disease: Necrotizing Enterocolitis
Necrotizing Enterocolitis
0.600 Biomarker disease BEFREE Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice. 22796522 2012
CUI: C0520459
Disease: Necrotizing Enterocolitis
Necrotizing Enterocolitis
0.600 AlteredExpression disease BEFREE Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis. 20976181 2011
CUI: C0520459
Disease: Necrotizing Enterocolitis
Necrotizing Enterocolitis
0.600 Biomarker disease RGD Ileal immune dysregulation in necrotizing enterocolitis: role of CD40/CD40L in the pathogenesis of disease. 21240009 2011
CUI: C0520459
Disease: Necrotizing Enterocolitis
Necrotizing Enterocolitis
0.600 Biomarker disease BEFREE Toll-like receptor-4 inhibits enterocyte proliferation via impaired beta-catenin signaling in necrotizing enterocolitis. 19786028 2010
CUI: C0520459
Disease: Necrotizing Enterocolitis
Necrotizing Enterocolitis
0.600 AlteredExpression disease BEFREE Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis. 19109197 2009
CUI: C0520459
Disease: Necrotizing Enterocolitis
Necrotizing Enterocolitis
0.600 Biomarker disease RGD Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. 19608731 2009
CUI: C0520459
Disease: Necrotizing Enterocolitis
Necrotizing Enterocolitis
0.600 Biomarker disease LHGDN TLR4 is functional and expressed in the developing intestinal mucosa; TLR4 signaling in enterocytes plays a critical role in the pathogenesis of necrotizing enterocolitis. 19109197 2009
CUI: C0520459
Disease: Necrotizing Enterocolitis
Necrotizing Enterocolitis
0.600 Biomarker disease LHGDN demonstrate a critical role for TLR4 in the development of necrotizing enterocolitis through effects on enterocyte injury and repair, identify a novel TLR4-focal adhesion kinase association in regulating enterocyte migration 17878380 2007
CUI: C0520459
Disease: Necrotizing Enterocolitis
Necrotizing Enterocolitis
0.600 GeneticVariation disease BEFREE Genetic polymorphisms of CD14, toll-like receptor 4, and caspase-recruitment domain 15 are not associated with necrotizing enterocolitis in very low birth weight infants. 16385250 2006
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.510 Biomarker disease CTD_human Relevance of megalin receptor injury with nuclear factor-kappa B upregulation in acute kidney injury induced in rats. 29286200 2018
CUI: C0035078
Disease: Kidney Failure
Kidney Failure
0.510 Biomarker disease CTD_human TLR4-mediated inflammation is a key pathogenic event leading to kidney damage and fibrosis in cyclosporine nephrotoxicity. 27585667 2017
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.510 Biomarker disease BEFREE Targeting the HMGB1-TLR4 pathway might enable development of a new therapeutic strategy to improve the outcomes of severely ill patients with both acute lung and acute kidney injury. 24646859 2015
CUI: C0011882
Disease: Diabetic Neuropathies
Diabetic Neuropathies
0.510 Biomarker group RGD It may imply that TLR4 could be a novel target for treating diabetic neuropathy. 22910613 2012
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.510 Therapeutic disease RGD Prevention of acute kidney injury in a rodent model of cirrhosis following selective gut decontamination is associated with reduced renal TLR4 expression. 22266601 2012
CUI: C0035078
Disease: Kidney Failure
Kidney Failure
0.510 Biomarker disease BEFREE Chronic rejection patients have significantly increased TLR4 and myeloid differentiation factor 88 compared with operationally tolerant patients, who resemble healthy volunteers and nontransplant patients with renal failure. 18622290 2008
CUI: C0035078
Disease: Kidney Failure
Kidney Failure
0.510 Biomarker disease RGD Cyclosporine-induced renal injury induces toll-like receptor and maturation of dendritic cells. 16177646 2005
CUI: C0011882
Disease: Diabetic Neuropathies
Diabetic Neuropathies
0.510 GeneticVariation group LHGDN Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with reduced prevalence of diabetic neuropathy in type 2, but not in type 1, diabetes. 14693986 2004
CUI: C0011882
Disease: Diabetic Neuropathies
Diabetic Neuropathies
0.510 GeneticVariation group BEFREE Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes. 14693986 2004
CUI: C0011882
Disease: Diabetic Neuropathies
Diabetic Neuropathies
0.510 Biomarker group CTD_human Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes. 14693986 2004
CUI: C0011882
Disease: Diabetic Neuropathies
Diabetic Neuropathies
0.510 Biomarker group CTD_human Our data indicate that Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with reduced prevalence of diabetic neuropathy in type 2, but not in type 1, diabetes. 14693986 2004