TNFAIP3, TNF alpha induced protein 3, 7128

N. diseases: 212; N. variants: 29
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.360 Biomarker group BEFREE Tumor necrosis factor, α-induced protein 3 (TNFAIP3) which encodes a ubiquitin-modifying enzyme (A20), acts as a negative regulator of the NF-κB pathway, and in lymphoma and autoimmune diseases it is frequently inactivated by mutations and/or deletions. 26986245 2016
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.360 Biomarker group BEFREE This study confirms the role of A20 impairment in pSS-associated lymphoma. 26338037 2016
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.360 GeneticVariation group BEFREE A20 (TNFAIP3) deletion in Epstein-Barr virus-associated lymphoproliferative disorders/lymphomas. 23418597 2013
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.360 GeneticVariation group BEFREE Twelve (60%) of the 20 patients with paired germline and lymphoma TNFAIP3 sequence data had functional abnormalities of A20: 6 in germline DNA, 5 in lymphoma DNA, and 1 in both. 24159176 2013
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.360 GeneticVariation group BEFREE The tumor suppressor A20 [also known as TNFAIP3 (tumor necrosis factor-α-induced protein 3)] inhibits an upstream activator of NF-κB and is often mutated in lymphomas. 23901138 2013
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.360 GeneticVariation group BEFREE A new study identifies somatic mutations in TNFAIP3, the gene encoding the NF-kappaB inhibitor A20, in Hodgkin lymphomas and primary mediastinal lymphomas. 19380636 2009
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.360 CausalMutation group CGI
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.360 GenomicAlterations group CGI