TP53, tumor protein p53, 7157

N. diseases: 2494; N. variants: 527
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 GeneticVariation group BEFREE A noncoding polymorphism (rs78378222) in TP53, carried by scores of millions of people, was previously associated with moderate risk of brain tumors and other neoplasms. 31699989 2019
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 Biomarker group BEFREE Finally, loss of APE1 in combination with p53 inactivation resulted in a profound susceptibility to brain tumors, including medulloblastoma and glioblastoma, implicating oxidative DNA lesions as an etiologic agent in these diseases. 30538199 2018
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 Biomarker group BEFREE Brain tumor development was slower in the Polb and p53 double null animals than in the Xrcc1 and p53 double knockout animals. 30274781 2018
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 Biomarker group BEFREE Glioblastoma is the most malignant and invasive brain tumor with extremely poor prognosis. p53-inducible gene 3, a downstream molecule of the tumor suppressor p53, has been found involved in apoptosis and oxidative stress response. 28351326 2017
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 Biomarker group BEFREE Oxidant and anti-oxidant status in common brain tumors: Correlation to TP53 and human biliverdin reductase. 28499219 2017
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 Biomarker group BEFREE Here we demonstrate that combined inactivation of the XRCC4 non-homologous end-joining (NHEJ) DNA repair gene and p53 efficiently induces brain tumours with hallmark characteristics of human proneural/classical glioblastoma. 28094268 2017
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 Biomarker group BEFREE Our findings provide novel information about p53 involvement in meningeal brain tumours and reveal the complex relationship between Wnt and p53 signalling, they suggest an important role for beta-catenin in these tumours. 27292269 2016
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 GeneticVariation group CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 Biomarker group BEFREE Hence, Notch signaling cooperates with p53 to restrict cell proliferation and tumor growth in mouse models of human brain tumors. 26669487 2015
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 AlteredExpression group BEFREE We show here that parkin levels inversely correlate to brain tumor grade and p53 levels in oligodendrogliomas, mixed gliomas and glioblastomas. 23644658 2014
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 AlteredExpression group BEFREE Finally, p53 expression levels in brain tumors were comparable to Bcl-6 levels. 25038272 2014
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 GeneticVariation group BEFREE The presence and patterns of TP53 mutations are associated mainly with the age at the onset and with the development of less malignant brain tumors. 24481542 2014
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 GeneticVariation group BEFREE Interestingly, ALT attenuated the poor outcome conferred by TP53 mutations in specific pediatric brain tumors. 25315281 2014
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 AlteredExpression group BEFREE Moreover, Ad-mΔ19/p53VPΔ30 showed a greater antitumor effect and increased survival rates of mice with U343 brain cancer xenografts that expressed wild-type p53 and high Mdm2 levels. 22248367 2012
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 GeneticVariation group BEFREE We report the whole-genome sequencing-based analysis of a Sonic-Hedgehog medulloblastoma (SHH-MB) brain tumor from a patient with a germline TP53 mutation (Li-Fraumeni syndrome), uncovering massive, complex chromosome rearrangements. 22265402 2012
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 Biomarker group BEFREE We also used targeted genotyping to examine the role of tumor-related genes in brain tumor development and specifically examined the clinical consequences of MAE at TP53 and IDH1. 22144470 2012
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 GeneticVariation group BEFREE Clinically relevant TP53 germline mutations were identified in three of the four patients (75%) with a family history of at least two LFS-linked cancers (breast, bone or soft tissue sarcoma, brain tumors or adrenocortical cancer); 1 of the 17 patients (6%) with a family history of breast cancer only, and 1 of the 62 patients (< 2%) with no family history of breast or LFS-linked cancers. 22507745 2012
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 Biomarker group BEFREE The effect of p53 status on response to TMZ was explored in traditional glioma cell lines (U87MG, U251MG, U343MG, U373MG, SF767, LN443 and LNZ308) and brain tumor initiating cells (BTICs--BT012, BT025, BT042, BT048, BT060 and BT069) in two ways: (1) inhibition of p53 by RNAi and (2) sensitivity in relation to intrinsic p53 status, either wild-type or mutant. 20593219 2011
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 GeneticVariation group BEFREE The authors here present a family with pR337P mutation in TP53 gene who had a child with acute lymphoblastic leukemia (ALL) and associated adrenocortical carcinoma as a case 1 and his cousin with brain tumor as a case 2. 20426520 2010
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 AlteredExpression group BEFREE Negative regulation of p53 by the long isoform of ErbB3 binding protein Ebp1 in brain tumors. 21098709 2010
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 GeneticVariation group BEFREE These mice showed no phenotype, but on a Trp53 null background a majority of them developed brain tumors. 19115382 2009
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 GeneticVariation group BEFREE Polymorphisms and DNA methylation of gene TP53 associated with extra-axial brain tumors. 19224462 2009
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 GeneticVariation group BEFREE Germ-line mutations of the TP53 gene are known to cause Li-Fraumeni syndrome, an autosomal, dominantly inherited, high-penetrance cancer-predisposition syndrome characterized by the occurrence of a variety of cancers, mainly soft tissue sarcomas, adrenocortical carcinoma, leukemia, breast cancer, and brain tumors. 20017945 2009
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 GeneticVariation group BEFREE Mutations in TP53 and RB1 have been shown to participate in the development of malignant brain tumors. 18575738 2008
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 GeneticVariation group BEFREE Germline TP53 mutations predispose to a rare familial cancer syndrome, the Li-Fraumeni Syndrome (LFS), characterized by the early onset of multiple cancers including childhood adrenocortical carcinomas, sarcomas and brain tumors, and breast and colon cancer in young adults. 18248785 2008