Brain Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
A noncoding polymorphism (rs78378222) in TP53, carried by scores of millions of people, was previously associated with moderate risk of brain tumors and other neoplasms.
|
31699989 |
2019 |
Brain Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Finally, loss of APE1 in combination with p53 inactivation resulted in a profound susceptibility to brain tumors, including medulloblastoma and glioblastoma, implicating oxidative DNA lesions as an etiologic agent in these diseases.
|
30538199 |
2018 |
Brain Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Brain tumor development was slower in the Polb and p53 double null animals than in the Xrcc1 and p53 double knockout animals.
|
30274781 |
2018 |
Brain Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Glioblastoma is the most malignant and invasive brain tumor with extremely poor prognosis. p53-inducible gene 3, a downstream molecule of the tumor suppressor p53, has been found involved in apoptosis and oxidative stress response.
|
28351326 |
2017 |
Brain Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Oxidant and anti-oxidant status in common brain tumors: Correlation to TP53 and human biliverdin reductase.
|
28499219 |
2017 |
Brain Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Here we demonstrate that combined inactivation of the XRCC4 non-homologous end-joining (NHEJ) DNA repair gene and p53 efficiently induces brain tumours with hallmark characteristics of human proneural/classical glioblastoma.
|
28094268 |
2017 |
Brain Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Our findings provide novel information about p53 involvement in meningeal brain tumours and reveal the complex relationship between Wnt and p53 signalling, they suggest an important role for beta-catenin in these tumours.
|
27292269 |
2016 |
Brain Neoplasms
|
0.700 |
GeneticVariation
|
group |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
Brain Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Hence, Notch signaling cooperates with p53 to restrict cell proliferation and tumor growth in mouse models of human brain tumors.
|
26669487 |
2015 |
Brain Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
We show here that parkin levels inversely correlate to brain tumor grade and p53 levels in oligodendrogliomas, mixed gliomas and glioblastomas.
|
23644658 |
2014 |
Brain Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Finally, p53 expression levels in brain tumors were comparable to Bcl-6 levels.
|
25038272 |
2014 |
Brain Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The presence and patterns of TP53 mutations are associated mainly with the age at the onset and with the development of less malignant brain tumors.
|
24481542 |
2014 |
Brain Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Interestingly, ALT attenuated the poor outcome conferred by TP53 mutations in specific pediatric brain tumors.
|
25315281 |
2014 |
Brain Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Moreover, Ad-mΔ19/p53VPΔ30 showed a greater antitumor effect and increased survival rates of mice with U343 brain cancer xenografts that expressed wild-type p53 and high Mdm2 levels.
|
22248367 |
2012 |
Brain Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
We report the whole-genome sequencing-based analysis of a Sonic-Hedgehog medulloblastoma (SHH-MB) brain tumor from a patient with a germline TP53 mutation (Li-Fraumeni syndrome), uncovering massive, complex chromosome rearrangements.
|
22265402 |
2012 |
Brain Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
We also used targeted genotyping to examine the role of tumor-related genes in brain tumor development and specifically examined the clinical consequences of MAE at TP53 and IDH1.
|
22144470 |
2012 |
Brain Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Clinically relevant TP53 germline mutations were identified in three of the four patients (75%) with a family history of at least two LFS-linked cancers (breast, bone or soft tissue sarcoma, brain tumors or adrenocortical cancer); 1 of the 17 patients (6%) with a family history of breast cancer only, and 1 of the 62 patients (< 2%) with no family history of breast or LFS-linked cancers.
|
22507745 |
2012 |
Brain Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
The effect of p53 status on response to TMZ was explored in traditional glioma cell lines (U87MG, U251MG, U343MG, U373MG, SF767, LN443 and LNZ308) and brain tumor initiating cells (BTICs--BT012, BT025, BT042, BT048, BT060 and BT069) in two ways: (1) inhibition of p53 by RNAi and (2) sensitivity in relation to intrinsic p53 status, either wild-type or mutant.
|
20593219 |
2011 |
Brain Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The authors here present a family with pR337P mutation in TP53 gene who had a child with acute lymphoblastic leukemia (ALL) and associated adrenocortical carcinoma as a case 1 and his cousin with brain tumor as a case 2.
|
20426520 |
2010 |
Brain Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Negative regulation of p53 by the long isoform of ErbB3 binding protein Ebp1 in brain tumors.
|
21098709 |
2010 |
Brain Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
These mice showed no phenotype, but on a Trp53 null background a majority of them developed brain tumors.
|
19115382 |
2009 |
Brain Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms and DNA methylation of gene TP53 associated with extra-axial brain tumors.
|
19224462 |
2009 |
Brain Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Germ-line mutations of the TP53 gene are known to cause Li-Fraumeni syndrome, an autosomal, dominantly inherited, high-penetrance cancer-predisposition syndrome characterized by the occurrence of a variety of cancers, mainly soft tissue sarcomas, adrenocortical carcinoma, leukemia, breast cancer, and brain tumors.
|
20017945 |
2009 |
Brain Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Mutations in TP53 and RB1 have been shown to participate in the development of malignant brain tumors.
|
18575738 |
2008 |
Brain Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Germline TP53 mutations predispose to a rare familial cancer syndrome, the Li-Fraumeni Syndrome (LFS), characterized by the early onset of multiple cancers including childhood adrenocortical carcinomas, sarcomas and brain tumors, and breast and colon cancer in young adults.
|
18248785 |
2008 |