|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Associations between p53 immunostaining and SCC were not found.
|
30881503 |
2019 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Fifteen (88%) of 17 successfully analyzed HPV-unrelated SCCs harbored TP53 mutations.
|
31437519 |
2019 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Low-Concentration PTX And RSL3 Inhibits Tumor Cell Growth Synergistically By Inducing Ferroptosis In Mutant p53 Hypopharyngeal Squamous Carcinoma.
|
31819616 |
2019 |
|
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The expression of p53 in adenocarcinoma was generally higher than that of squamous cell carcinoma and large cell carcinoma.
|
31186777 |
2019 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Tumors with high TMB were more prevalent in squamous cell carcinoma (P = .017) and those with a TP53 mutation (P < .0001).
|
31734072 |
2019 |
|
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
ΔNp63α, a proto-oncogene in the p53 family of transcription factors, is overexpressed in squamous cell carcinoma (SCC) and associated with poor prognosis and survival.
|
31601649 |
2019 |
|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The role of p53 status on the synergistic effect of CKD-602 and cisplatin on oral squamous cell carcinoma cell lines.
|
30478746 |
2019 |
|
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Eighteen squamous cell carcinomas (69%) expressed p53 and 18 had mutations in exons 5-8 of TP53.
|
30998743 |
2019 |
|
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> p16 and p53 were detected in 50.7 and 57.3% of adenocarcinoma (ADCs; n = 75), and 35.2 and 63.6% of squamous cell carcinoma (n = 88).
|
31157548 |
2019 |
|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Two cases exhibited strong p53 positivity in the high-grade squamous intraepithelial lesion/squamous cell carcinoma component analogous to that seen in HPV-negative differentiated intraepithelial lesions of the external genitalia.
|
30312218 |
2019 |
|
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These results suggested that PaH was a promising sensitizer that can be combined with light to produce significant anti-tumor effects in oral squamous cell carcinoma via enhanced ROS production and up-regulated expression of p53.
|
31099374 |
2019 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Absence of disruptive TP53 mutations in high-risk human papillomavirus-driven neck squamous cell carcinoma of unknown primary.
|
31414564 |
2019 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In summary, squamous cell carcinomas recurred in the residual vulvar dermatosis independent of TP53 gene mutational status of the primary squamous cell carcinoma.
|
30291345 |
2019 |
|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry of the SCC showed positive staining for p53 and Ki67 and negative staining for thyroglobulin.
|
29914738 |
2018 |
|
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We found EGFR expression is higher in the squamous cell carcinomas than in adenocarcinomas (p=0.043), and that nuclear p53 staining correlated with lower differentiated squamous tumors (p=0.034).
|
29731995 |
2018 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Variations in the TP53 gene were seen in all NSCLC subtypes, including six ADC (13.63%), seven SCC (15.9%) and two LCC (4.54%).
|
30048458 |
2018 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to evaluate the association of HPV and HIV status, p16 expression level and TP53 mutations with the absence of residual tumors (local response) in Squamous Cell Carcinoma (SCC) of the anal canal after chemoradiotherapy.
|
29466950 |
2018 |
|
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Similarly, in SCCs, it was observed that lesser the differentiation, more is the expression of both p53 and EGFR.
|
29516925 |
2018 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Effect of TP53 rs1042522 on the susceptibility of patients to oral squamous cell carcinoma and oral leukoplakia: a meta-analysis.
|
30126398 |
2018 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Further, these taxa, including Acidovorax, exhibit higher abundance among the subset of squamous cell carcinoma cases with TP53 mutations, an association not seen in adenocarcinomas.
|
30143034 |
2018 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Here, we investigated tissue-level constraints on clonal progenitor behavior by inducing a single-allele p53 mutation (Trp53<sup>R245W</sup>; p53<sup>∗/wt</sup>), prevalent in normal human epidermis and squamous cell carcinoma, in transgenic mouse epidermis. p53<sup>∗/wt</sup> progenitors initially outcompeted wild-type cells due to enhanced proliferation, but subsequently reverted toward normal dynamics and homeostasis.
|
30269904 |
2018 |
|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The data obtained in both artificial and spontaneous in vitro models suggest that FcaPV-2 E6 degrades p53 through a molecular mechanism similar to HR HPVs, possibly contributing to the development of feline SCC.
|
30510267 |
2018 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Clinically, TP53 mutations are largely associated with poor survival and tumor resistance to radiotherapy and chemotherapy in OSCC patients, which makes the TP53 mutation status a potentially useful molecular marker prognostic and predictive of clinical response in these patients.
|
29489434 |
2018 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Ten of the 14 tumors that remained classified as SCC had detectable TP53 mutations.
|
28709693 |
2017 |
|
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
By immunohistochemistry, we studied the expression of P53 protein and relative isoforms in benign papillomas (PA, n=9), inverted papilloma (IPA, n=10) and squamous cell carcinomas (SCC, n=21).
|
27411919 |
2017 |