TP53, tumor protein p53, 7157

N. diseases: 2494; N. variants: 527
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 Biomarker disease BEFREE Although many genes, such as p53 and Rb1, have been shown to be mutated, deregulation of the canonical Wnt/β-catenin signaling pathway is frequently observed in OS. 31595984 2020
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 Biomarker disease BEFREE MicroRNA-504 modulates osteosarcoma cell chemoresistance to cisplatin by targeting p53. 30675226 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 Biomarker disease BEFREE The co-occurrence of cellular aneuploidy, complex chromosomal rearrangements and p53 dysfunction is a striking feature of some osteosarcomas. 30508038 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 Biomarker disease BEFREE Anti-cancer drug adriamycin (ADR) treatment induced cell death in <i>p53</i>-wild-type human osteosarcoma U2OS cells, and this was accompanied by a remarkable accumulation of p53 and γH2AX. 30868056 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 Biomarker disease BEFREE At advanced ages, p53 mKO mice began to die prematurely and had an increased incidence of osteosarcoma, precluding analyses of muscle mass and function in very old p53 mKO mice. 31465716 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 AlteredExpression disease BEFREE A polysaccharide from Enterobacter cloacae induces apoptosis of human osteosarcoma cells through the activation of p53 and mitochondrial intrinsic pathway. 30336239 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 GeneticVariation disease BEFREE By utilizing the clinical information in GSE21257, 10 critical genes associated with osteosarcoma prognosis were obtained, including CTP synthase 2 (CTPS2), tumor protein p53 inducible protein 3 (TP53I3) and solute carrier family 1 member 1 (SLC1A1). 31173206 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 AlteredExpression disease BEFREE Western blot was conducted to detect the expression of p53 after the knockdown of SNHG7 in osteosarcoma cells. 31114984 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 Biomarker disease BEFREE Aberrant expression of the transcription factor, runt-related transcription factor 2 (RUNX2), is a key pathological feature in osteosarcoma and associated with loss of p53 and miR-34 expression. 30637720 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 Biomarker disease BEFREE Furthermore, LINC01116 is involved in the development of osteosarcoma by binding to EZH2 to regulate expressions of PTEN and p53. 31486480 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 GeneticVariation disease BEFREE TP53 structural rearrangements have been previously reported in a significant subset of osteosarcomas, where they result in loss of p53 protein expression by immunohistochemistry. 31216325 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 Biomarker disease BEFREE In conclusion, our study showed that the p53 and p38α MAPK signal axis facilitated HOXA5's role in inhibiting growth and stimulating apoptosis of osteosarcoma cells. 30521886 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 AlteredExpression disease BEFREE Note that this action is independent of p53 status, because VCA-1 induced similar levels of apoptosis in two different panels of cell lines (HCT116 p53- wild-type vs. HCT116 p53-knockout colon cancer cells, and p53-expressing U2OS vs. p53-deficient saos2 osteosarcoma cancer cells). 29773887 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 GeneticVariation disease BEFREE In the present meta-analysis, we aimed to elucidate the associations of TP53 rs1042522 genetic polymorphism with the risk of osteosarcoma or Ewing sarcoma. 30833364 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 AlteredExpression disease BEFREE We have also demonstrated that the knock-out or inhibition of mutant TP53 decreased the expression of the oncogene IGF-1R, anti-apoptotic proteins Bcl-2, and Survivin in osteosarcoma cells. 30667081 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 GeneticVariation disease BEFREE Although mutations in TP53 were thought to be relatively low in sarcomas, modern techniques including whole-genome sequencing have recently illuminated unappreciated alterations in TP53 in osteosarcoma. 31276706 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 Biomarker disease BEFREE In this study, we analyzed modulatory effects on the cell cycle by viscumTT in three osteosarcoma cell lines with various TP53 statuses. 29636527 2018
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 Biomarker disease BEFREE Importantly, MG-63 human osteosarcoma xenograft growth in nude mice was significantly suppressed in vivo through triggering apoptosis and p53 phosphorylation. 29323455 2018
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 Biomarker disease BEFREE Here we looked for novel genes potentially (co)regulated by p53 and NF-κB using integrative genomics screening in human osteosarcoma U2-OS cells irradiated with a high dose (4 and 10 Gy). 30419821 2018
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 AlteredExpression disease BEFREE While p53 and Rb inactivation occurs in most osteosarcomas, the landscape of associated driver mutations has proved extensive. 29435436 2018
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 GeneticVariation disease BEFREE This study found an association between alterations in the TP53 gene and the synergy score for combination treatment with doxorubicin and an Src kinase inhibitor using human osteosarcoma cell lines (MG63 and U2OS) and human colon cancer cell line. 30124118 2018
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 AlteredExpression disease BEFREE After SOX4 gene silencing, the protein expression levels of Bax, Caspase-3, and P53 in osteosarcoma cells were significantly elevated, while the protein expression levels of Bcl-2, MMP2, and MMP9 were obviously decreased. 29038881 2018
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 AlteredExpression disease BEFREE Mechanistically, the relative protein expression level of p-PI3K, p-Akt and Bcl-2 were significantly increased and the relative expression of P53 was significantly decreased in osteosarcoma cells after transfection with lncRNA-LINC00628. 30280767 2018
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 GeneticVariation disease BEFREE ONZIN Upregulation by Mutant p53 Contributes to Osteosarcoma Metastasis Through the CXCL5-MAPK Signaling Pathway. 30041188 2018
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 GeneticVariation disease BEFREE How mutation of p53 enables OS development from osteoblastic lineage cells is poorly understood. 30154459 2018