Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
Complement C3 Inhibitor Pegcetacoplan for Geographic Atrophy Secondary to Age-Related Macular Degeneration: A Randomized Phase 2 Trial.
|
31474439 |
2020 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide analysis of disease progression in age-related macular degeneration.
|
29346644 |
2018 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this post hoc analysis of cross-sectional data from US participants in the Comparison of AMD Treatments Trials, genotyping was performed in 835 participants with TaqMan assays for the SNPs rs1061170 (Y402H variant in CFH), rs800292 (rs800292" genes_norm="3075">I62V variant in CFH), rs10490924 (rs10490924;s10490924" genes_norm="387715;717">A69S variant in ARMS2), rs11200638 (HTRA1), rs547154 (C2), rs2230199 (rs2230199" genes_norm="5654;718">R102G variant in C3), rs10468017 (LIPC), and rs4151667 (L9H variant in CFB).
|
29801032 |
2018 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association between genetic variation of complement C3 and the susceptibility to advanced age-related macular degeneration: a meta-analysis.
|
30352574 |
2018 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association of polymorphisms in complement component 3 with age-related macular degeneration in an Iranian population.
|
27029644 |
2017 |
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
Joint association of complement component 3 and CC-cytokine ligand2 (CCL2) or complement component 3 and CFH polymorphisms in age-related macular degeneration.
|
28095095 |
2017 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association of rare variants in the CFH, CFI, C9, and C3 genes with AMD, serum levels of corresponding proteins, and C3b degradation ability of CFH and CFI variant carriers.
|
27918759 |
2017 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.
|
26691988 |
2016 |
COMPLEMENT COMPONENT 3 DEFICIENCY, AUTOSOMAL RECESSIVE
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
A Familial C3GN Secondary to Defective C3 Regulation by Complement Receptor 1 and Complement Factor H.
|
26471127 |
2016 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The association between the rs2230199 C>G single nucleotide polymorphism (SNP) in complement component 3 and age-related macular degeneration (AMD) risk has been examined extensively but the results are not consistent among studies.
|
26505407 |
2015 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Based on the search criteria for manuscripts reporting AMD susceptibility related to CC3 in nine SNPs, 57 case-control studies from 22 different articles were retrieved.
|
25688879 |
2015 |
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
Complement C3, C2, and factor B gene polymorphisms and age-related macular degeneration in a Greek cohort study.
|
24519512 |
2014 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To explore whether additional rare variants in the C3 gene are associated with AMD, we sequenced all coding exons in 84 unrelated AMD cases.
|
24736606 |
2014 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated the associations of haplotype-tagging single nucleotide polymorphisms (SNPs) in the complement component 3 (C3) gene with both neovascular AMD and PCV, and potential epistatic effects on C3.
|
25388911 |
2014 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Seven new loci associated with age-related macular degeneration.
|
23455636 |
2013 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
PPARGC1A influences activation of the AMD-associated complement component 3 (C3) promoter fragment and CFB influences activation and proteolysis of C3.
|
23335958 |
2013 |
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
CTD_human |
Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration.
|
24036952 |
2013 |
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
CTD_human |
Identification of a rare coding variant in complement 3 associated with age-related macular degeneration.
|
24036949 |
2013 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Seven new loci associated with age-related macular degeneration.
|
23455636 |
2013 |
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
CTD_human |
A rare nonsynonymous sequence variant in C3 is associated with high risk of age-related macular degeneration.
|
24036950 |
2013 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.
|
22705344 |
2012 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
While significant but modest associations were identified between the complement factor H, the age-related maculopathy susceptibility protein 2, and the complement component 3 single nucleotide polymorphisms and AD, these were different in direction or genetic model to that observed in AMD.
|
22300950 |
2012 |
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
Systematic review and meta-analysis of the association between complement component 3 and age-related macular degeneration: a HuGE review and meta-analysis.
|
21576320 |
2011 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
|
21665990 |
2011 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
|
21665990 |
2011 |