C3AR1, complement C3a receptor 1, 719

N. diseases: 73; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036690
Disease: Septicemia
Septicemia
0.020 Biomarker disease BEFREE Our results highlight a novel role for complement and the Cpb1-C3-C3aR pathway in proinflammatory signaling, caspase-11 cell death, and sepsis severity. 27697835 2016
CUI: C0036690
Disease: Septicemia
Septicemia
0.020 AlteredExpression disease BEFREE These results demonstrate the expression of C3aR and C5aR by cells endogenous to the lung, and, given the participation of bronchial epithelial and smooth muscle cells in the pathology of diseases such as sepsis and asthma, the data suggest a role for these receptors during lung inflammation. 11160252 2001