TSC1, TSC complex subunit 1, 7248

N. diseases: 391; N. variants: 155
Disease: Liver carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.320 GeneticVariation disease BEFREE Taken together, our findings suggest the significance of previously undocumented mutation-dependent mTOR hyperactivation and frequent <i>TSC1/2</i> mutations in HBV-associated HCCs. 27974549 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.320 Biomarker disease BEFREE Furthermore, by taking account of genomic mutations causing transcriptional aberrations, we could improve the sensitivity of deleterious mutation detection in known cancer driver genes (TP53, AXIN1, ARID2, RPS6KA3), and identified recurrent disruptions in putative cancer driver genes such as HNF4A, CPS1, TSC1 and THRAP3 in HCCs. 25526364 2014
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.320 Biomarker disease CTD_human High-resolution characterization of a hepatocellular carcinoma genome. 21499249 2011