|
Kidney Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
We report here that X<sub>c</sub><sup>-</sup> cystine/glutamate antiporter (xCT) was elevated in Tsc2<sup>-/-</sup> or Pten<sup>-/-</sup> cells, Tsc1 knockout mouse tissues and TSC2-deficient human kidney tumor. xCT was transcriptionally boosted by mTOR-mediated Oct1 signaling cascade.
|
30760873 |
2019 |
|
Kidney Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tsc2+/- mice at increasing age groups at 8 and 10 months were exposed to repeated doses of gamma radiation (0.4 Gy × 5) and assessed for aggravated kidney tumor formation at 2 months post-irradiation.
|
30508035 |
2019 |
|
Kidney Neoplasm
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These data provide the first evidence that tuberin plays a novel role in regulating ROS generation, NADPH oxidase activity, and Nox expression that may potentially be involved in development of kidney tumor in patients with tuberous sclerosis complex.
|
27278252 |
2016 |
|
Kidney Neoplasm
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, a significant increase in phospho-Akt/tuberin expression was associated with an increase in Ki67 expression and activation of mTOR in kidney tumor with or without diabetes compared to diabetes alone.
|
24797175 |
2014 |
|
Kidney Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data comprise the first report to provide the role of Akt/tuberin/mTORC1/2 in the regulation of N-cadherin and vimentin that are involved in the progression of fibrosis in kidney tumor of TSC patients.
|
25149531 |
2014 |
|
Kidney Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the present study, we investigated the potential role of tuberin/mTOR pathway in the regulation of cell fibrosis in AML cells and kidney tumor tissue from tuberous sclerosis complex (TSC) patients.
|
23705901 |
2013 |
|
Kidney Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
UPR activation and apoptosis were also detected in Tsc2-deficient kidney tumors.
|
23699409 |
2013 |
|
Kidney Neoplasm
|
0.400 |
Biomarker
|
disease |
CTD_human |
Renal tumors derived from 2,3,5-tris-(glutathion-S-yl)hydroquinone (TGHQ)-treated Tsc-2(EK/+) rats, and null for tuberin, display elevated nuclear and cytosolic p27, with parallel increases in cytosolic cyclin D1 levels.
|
21693435 |
2011 |
|
Kidney Neoplasm
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A complete deficiency in tuberin is associated with loss of AP4 and OGG1 expression in kidney tumour from Eker rats and the accumulation of significant levels of 8-oxo-deoxyguanosine.
|
20837600 |
2010 |
|
Kidney Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mice that are heterozygous for the del3 allele have a markedly reduced kidney tumor burden in comparison with conventional Tsc2(+/-) mice.
|
19357198 |
2009 |
|
Kidney Neoplasm
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study is to determine the effect of tuberin-deficiency on OGG1 protein and mRNA levels as well as on 8-oxodG levels in kidney tumors from patients with TSC.
|
19265534 |
2009 |
|
Kidney Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Phase I/II clinical trials of the mTORC1 inhibitor rapamycin have demonstrated reduction in size of tuberous-sclerosis- and LAM-associated renal tumours (angiomyolipomas) and some evidence for reversible improvement in lung function in patients with LAM.
|
19143643 |
2009 |
|
Kidney Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we show that both phosphatidylinositol 3-kinase-dependent and phosphatidylinositol 3-kinase-independent mTORC2 substrates are affected by loss of the TSC1-TSC2 complex in cell culture models and kidney tumors from both Tsc2(+/-) mice (adenoma) and TSC patients (angiomyolipoma).
|
19602587 |
2009 |
|
Kidney Neoplasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, total beta-catenin protein levels were found to be elevated in the TSC2-related renal tumors.
|
12511557 |
2003 |
|
Kidney Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
In TSC associated kidney tumors and sporadic brain tumors the loss/reduction of tuberin has been shown.
|
12100629 |
2002 |
|
Kidney Neoplasm
|
0.400 |
Biomarker
|
disease |
CTD_human |
High extracellular signal-regulated kinase (ERK) activity occurred in the OSOM of Tsc2(EK/+) rats at 4 mo and in TGHQ-induced renal tumors.
|
12110509 |
2002 |
|
Kidney Neoplasm
|
0.400 |
Biomarker
|
disease |
CTD_human |
"Carcinogenicity of a nephrotoxic metabolite of the ""nongenotoxic"" carcinogen hydroquinone."
|
11170505 |
2001 |
|
Kidney Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Notably, however, development of renal tumors in Tsc1(+/-) mice was apparently slower than that in Tsc2(+/-) mice.
|
11438694 |
2001 |