|
Serum albumin measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
|
22286219 |
2012 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Increased glutamate uptake in astrocytes via propentofylline results in increased tumor cell apoptosis using the CNS-1 glioma model.
|
23695515 |
2013 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
We also see increased TTC4 expression in a variety of tumour lines derived from other tissues.
|
18320024 |
2008 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
We demonstrate that treatment with hsFlt3L leads to inhibition of tumor growth and significantly increased life span of animals implanted with syngeneic CNS-1 glioma cells.
|
15564139 |
2004 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Other members of this gene family have been implicated in tumorigenesis suggesting that TTC4 may represent a breast cancer tumor suppressor gene.
|
10639601 |
2000 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
TTC4, a novel candidate tumor suppressor gene at 1p31 is often mutated in malignant melanoma of the skin.
|
11126369 |
2000 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
To evaluate whether CpG-ODNs can induce rejection of established tumors, Lewis rats were inoculated intracerebrally with syngeneic CNS-1 glioma cells and subsequently injected with CpG-ODNs into the tumor bed.
|
10873101 |
2000 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Comparisons of CNS-1 to 9L gliosarcoma tumor were made.
|
7760095 |
1994 |
|
Glioma
|
0.030 |
Biomarker
|
disease |
BEFREE |
To study the relationship between astrocytes and tumor cells, the CNS-1 rodent glioma cell line was used.
|
23695515 |
2013 |
|
Malignant neoplasm of breast
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The gene was originally identified as being localized in a genomic region linked to breast cancer and subsequent studies on melanoma cell lines revealed point mutations in the TTC4 protein that may be associated with the progression of malignant melanoma.
|
18320024 |
2008 |
|
Breast Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The gene was originally identified as being localized in a genomic region linked to breast cancer and subsequent studies on melanoma cell lines revealed point mutations in the TTC4 protein that may be associated with the progression of malignant melanoma.
|
18320024 |
2008 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
Other members of this gene family have been implicated in tumorigenesis suggesting that TTC4 may represent a breast cancer tumor suppressor gene.
|
10639601 |
2000 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Other members of this gene family have been implicated in tumorigenesis suggesting that TTC4 may represent a breast cancer tumor suppressor gene.
|
10639601 |
2000 |
|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
A preliminary screen of human breast cancer cell lines shows that TTC4 is expressed in all cases, but SSCP analysis of the coding region of this gene following RT-PCR failed to reveal any mutations.
|
9933562 |
1999 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
A preliminary screen of human breast cancer cell lines shows that TTC4 is expressed in all cases, but SSCP analysis of the coding region of this gene following RT-PCR failed to reveal any mutations.
|
9933562 |
1999 |
|
Glioma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Overexpression of a transmembrane isoform of neural cell adhesion molecule alters the invasiveness of rat CNS-1 glioma.
|
9581848 |
1998 |
|
Glioma
|
0.030 |
Biomarker
|
disease |
BEFREE |
A rat glioma model, CNS-1, with invasive characteristics similar to those of human gliomas: a comparison to 9L gliosarcoma.
|
7760095 |
1994 |
|
CNS disorder
|
0.020 |
Biomarker
|
group |
BEFREE |
Methods CSF status was designated as follows: CNS1, no blasts; CNS2a to 2c, < 5 WBCs/μL and blasts with/without ≥ 10 RBCs/μL or ≥ 5 WBCs/μL plus blasts, with WBCs ≥ 5 times the number of RBCs; CNS3a to 3c, ≥ 5 WBCs/μL plus blasts with/without ≥ 10 RBCs/μL or clinical signs of CNS disease.
|
28535084 |
2017 |
|
CNS disorder
|
0.020 |
Biomarker
|
group |
BEFREE |
Patients enrolled on Children's Cancer Group protocols 2861, 2891, 2941, and 2961 being treated for de novo AML were classified for the presence of CNS disease at diagnosis as CNS1 (<5 WBC in the CSF without blasts), CNS2 (<5 WBC in the CSF with blasts), or CNS3 (> or =5 WBC in the CSF with blasts).
|
20658610 |
2010 |
|
melanoma
|
0.020 |
AlteredExpression
|
disease |
LHGDN |
We show that TTC4 protein levels are raised in malignant melanoma cell lines compared to melanocytes.
|
18320024 |
2008 |
|
melanoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The gene was originally identified as being localized in a genomic region linked to breast cancer and subsequent studies on melanoma cell lines revealed point mutations in the TTC4 protein that may be associated with the progression of malignant melanoma.
|
18320024 |
2008 |
|
melanoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that TTC4 may participate in the pathogenesis of malignant melanomas of the skin.
|
11126369 |
2000 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
While immune checkpoint inhibitors (ICIs) have contributed to the development of therapeutic treatments for previously incurable advanced malignancies, they may induce immune-related adverse events (irAEs) in many organs including the CNS [1].
|
31655267 |
2020 |
|
Crigler Najjar syndrome, type 1
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In patients with complete UGT1A1 deficiency (type 1 CNS [CNS-I]), unconjugated bilirubin levels increase 3-6 mg/dL/day during the newborn period and reach neurologically dangerous levels between 5 and 14 days of age.
|
31495946 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
CNS1 deletion also did not alter the development of T1D or glucose tolerance despite increased pancreatic insulitis in pre-diabetic female NOD CNS1-/- mice.
|
31647813 |
2019 |