Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0034885
Disease: Rectal Neoplasms
Rectal Neoplasms
0.330 Biomarker group BEFREE High TS was only found in 9.3% of rectal tumors, but in 29.7% of colon cancers (p=0.0042). 23968134 2014
CUI: C0034885
Disease: Rectal Neoplasms
Rectal Neoplasms
0.330 GeneticVariation group BEFREE Germline thymidylate synthase and XRCC1 polymorphisms might be useful as predictive markers of rectal tumor response to neoadjuvant chemoradiotherapy with 5-fluorouracil. 21167658 2012
CUI: C0034885
Disease: Rectal Neoplasms
Rectal Neoplasms
0.330 Biomarker group CTD_human Prognostic value of histologic tumor regression, thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer UICC Stage II/III after neoadjuvant chemoradiotherapy. 16931962 2006
CUI: C0034885
Disease: Rectal Neoplasms
Rectal Neoplasms
0.330 AlteredExpression group BEFREE The aim of this study was to evaluate three potential molecular genetic markers of prognosis (p53, deleted in colorectal cancer gene, and thymidylate synthase) in Dukes Stage B and C low rectal tumors treated with adjuvant therapy and to determine whether they correlate with survival, local recurrence, or the pathologic response to adjuvant therapy (assessed by extent of tumor regression and tumor down-staging). 12576893 2003