TYMS, thymidylate synthetase, 7298

N. diseases: 406; N. variants: 19
Disease: Malignant neoplasm of ovary ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.330 Biomarker disease BEFREE Thirteen variants in the pyrimidine metabolism genes, DPYD, DPYS, PPAT, and TYMS, also interacted significantly with folate in a multivariant analysis (corrected p = 9.9 × 10⁻⁶) but collectively explained only 0.2% of OC risk. 25066213 2014
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.330 Biomarker disease CTD_human Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase. 21795601 2011
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.330 GeneticVariation disease BEFREE Biomarkers that distinguish ovarian carcinoma types are few, and TYMS rs495139 may provide a novel clue to type etiology. 20570913 2010
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.330 AlteredExpression disease BEFREE Thymidylate synthase activity as a prognostic factor in ovarian cancer. 8208516 1994