|
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment.
|
25944804 |
2015 |
|
Colorectal Neoplasms
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Combination of polymorphisms within 5' and 3' untranslated regions of thymidylate synthase gene modulates survival in 5 fluorouracil-treated colorectal cancer patients.
|
19082493 |
2009 |
|
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Prognostic significance of numeric aberrations of genes for thymidylate synthase, thymidine phosphorylase and dihydrofolate reductase in colorectal cancer.
|
18607850 |
2008 |
|
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Clinical implications of thymidylate synthetase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activity levels in colorectal carcinoma following radical resection and administration of adjuvant 5-FU chemotherapy.
|
18597678 |
2008 |
|
Colorectal Neoplasms
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients.
|
18245544 |
2008 |
|
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
LHGDN |
Copy-number analysis of topoisomerase and thymidylate synthase genes in frozen and FFPE DNAs of colorectal cancers.
|
18855534 |
2008 |
|
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.
|
18676755 |
2008 |
|
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Thymidylate synthase and microsatellite instability in colorectal cancer: implications for disease free survival, treatment response and survival with metastases.
|
17943475 |
2008 |
|
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Messenger RNA expression of TS and ERCC1 in colorectal cancer and matched liver metastasis.
|
19020759 |
2008 |
|
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis.
|
19020767 |
2008 |
|
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
LHGDN |
Microsatellite instability and the association with plasma homocysteine and thymidylate synthase in colorectal cancer.
|
18584349 |
2008 |
|
Colorectal Neoplasms
|
0.600 |
GeneticVariation
|
group |
LHGDN |
G>C SNP of thymidylate synthase with respect to colorectal cancer.
|
17716232 |
2007 |
|
Colorectal Neoplasms
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Combined analysis of genetic polymorphisms in thymidylate synthase, uridine diphosphate glucoronosyltransferase and X-ray cross complementing factor 1 genes as a prognostic factor in advanced colorectal cancer patients treated with 5-fluorouracil plus oxaliplatin or irinotecan.
|
17273745 |
2007 |
|
Colorectal Neoplasms
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Polymorphisms in the thymidylate synthase and dihydropyrimidine dehydrogenase genes predict response and toxicity to capecitabine-raltitrexed in colorectal cancer.
|
17203168 |
2007 |
|
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Median gene expression levels of TP and TS did not differ significantly between primary colorectal tumor and corresponding lymph node metastasis but median DPD gene expression levels in the lymph node metastases were significantly higher compared to matched primary colorectal tumors (p=0.015).
|
16391809 |
2006 |
|
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Lymph node status and TS gene expression are prognostic markers in stage II/III rectal cancer after neoadjuvant fluorouracil-based chemoradiotherapy.
|
16943523 |
2006 |
|
Colorectal Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In this study, the mRNA expression levels of these 81 selected genes and the genes of 5-FU-related enzymes, including thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and orotate phosphoribosyltransferase (OPRT), were measured using real-time quantitative RT-PCR assays of surgically resected materials from primary colorectal tumors in 22 patients.
|
16477629 |
2006 |
|
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer and normal mucosa in patients.
|
17047489 |
2006 |
|
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
We present a novel, standardized approach for TP, DPD, and TS mRNA quantification in archival tissue specimens and applied this to a large series of primary colorectal tumors.
|
16132996 |
2006 |
|
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
We present a novel, standardized approach for TP, DPD, and TS mRNA quantification in archival tissue specimens and applied this to a large series of primary colorectal tumors.
|
16132996 |
2006 |
|
Colorectal Neoplasms
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Thymidylate synthase expression pattern, expression level and single nucleotide polymorphism are predictors for disease-free survival in patients of colorectal cancer treated with 5-fluorouracil.
|
16596248 |
2006 |
|
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Influence of thymidylate synthase gene polymorphisms on the survival of colorectal cancer patients receiving adjuvant 5-fluorouracil.
|
16141798 |
2005 |
|
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Thymidylate synthase gene promoter polymorphisms are associated with TSmRNA expressions but not with microsatellite instability in colorectal cancer.
|
15736425 |
2005 |
|
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Immunohistochemical analysis of thymidylate synthase, p16(INK4a), cyclin-dependent kinase 4 and cyclin D1 in colorectal cancers receiving preoperative chemotherapy: significance of p16(INK4a)-mediated cellular arrest as an indicator of chemosensitivity to 5-fluorouracil.
|
15260847 |
2004 |
|
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
[Relationship between expression of thymidylate synthase and colorectal carcinoma].
|
15500737 |
2004 |