Amyotrophic Lateral Sclerosis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Dominant mutations in the RNA/DNA-binding protein TDP-43 have been linked to amyotrophic lateral sclerosis (ALS).
|
31067307 |
2019 |
Amyotrophic Lateral Sclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
TDP-43 (transactive- response DNA binding protein) amazes structural biologist as its aberrant ubiquitinated cytosolic inclusions is largely involved in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
|
30315897 |
2019 |
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Inhibitor of DNA-Binding Protein 4 Suppresses Cancer Metastasis through the Regulation of Epithelial Mesenchymal Transition in Lung Adenocarcinoma.
|
31847356 |
2019 |
Amyotrophic Lateral Sclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
A protein central to ALS is the nuclear RNA/DNA-binding protein, TDP-43.
|
30157956 |
2018 |
Neoplasm Metastasis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Our experimental data establish that among NF-κB target genes, Uev1A-regulated <i>CXCL1</i> expression plays a critical role in colon cell invasion and metastasis, a notion supported by the colon adenocarcinoma survey.
|
29662619 |
2018 |
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Ube2v1 promoted migration and invasion of CRC cells in vitro and tumor growth and metastasis of CRC cells in vivo.
|
30016968 |
2018 |
Amyotrophic Lateral Sclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Withania somnifera Reverses Transactive Response DNA Binding Protein 43 Proteinopathy in a Mouse Model of Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration.
|
27928708 |
2017 |
Neoplasm Metastasis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Interestingly, experimental depletion of UEV1 in MDA-MB-231 cells reduces MMP1 expression and prevents tumor formation and metastasis in a xenograft mouse model, while overexpression of MMP1 overrides the metastasis effects in UEV1-depleted cells.
|
25022892 |
2014 |
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
Uev1A promotes cell survival under serum starvation stress through the AKT-FOXO1-BIM axis in breast cancer cells, which unveals a potential therapeutic target in the treatment of breast cancers.
|
31827405 |
2019 |
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Uev1A promotes cell survival under serum starvation stress through the AKT-FOXO1-BIM axis in breast cancer cells, which unveals a potential therapeutic target in the treatment of breast cancers.
|
31827405 |
2019 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Ube2v1 promoted migration and invasion of CRC cells in vitro and tumor growth and metastasis of CRC cells in vivo.
|
30016968 |
2018 |
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
The E3 ligase RNF8 acts in cooperation with the heterodimeric E2 enzyme Ubc13/Uev1a to generate ubiquitin conjugates at the sides of DNA double-strand breaks, and recent findings suggest RNF8 as a potential therapeutic target for the treatment of breast cancer.
|
27909234 |
2017 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The above findings identify UEV1A as a potential OS tumor suppression gene, and shed lights to future OS diagnosis and treatment.
|
28771228 |
2017 |
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The E3 ligase RNF8 acts in cooperation with the heterodimeric E2 enzyme Ubc13/Uev1a to generate ubiquitin conjugates at the sides of DNA double-strand breaks, and recent findings suggest RNF8 as a potential therapeutic target for the treatment of breast cancer.
|
27909234 |
2017 |
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Previous reports have correlated the level of UEV1A expression with tumorigenesis; however, the detailed molecular events leading to tumors particularly breast cancer and metastasis are unclear.
|
25022892 |
2014 |
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Previous reports have correlated the level of UEV1A expression with tumorigenesis; however, the detailed molecular events leading to tumors particularly breast cancer and metastasis are unclear.
|
25022892 |
2014 |
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Previous reports have correlated the level of UEV1A expression with tumorigenesis; however, the detailed molecular events leading to tumors particularly breast cancer and metastasis are unclear.
|
25022892 |
2014 |
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results identify Uev1A as a potential therapeutic target in the treatment of metastatic colorectal cancers.
|
29662619 |
2018 |
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Ube2v1 promoted migration and invasion of CRC cells in vitro and tumor growth and metastasis of CRC cells in vivo.
|
30016968 |
2018 |
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
BORIS (CTCFL) is a DNA binding protein which is involved in tumorigenesis.
|
30323717 |
2018 |
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Our experimental data establish that among NF-κB target genes, Uev1A-regulated <i>CXCL1</i> expression plays a critical role in colon cell invasion and metastasis, a notion supported by the colon adenocarcinoma survey.
|
29662619 |
2018 |
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy.
|
30016968 |
2018 |
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
Uev1A-Ubc13 promotes colorectal cancer metastasis through regulating <i>CXCL1</i> expression via NF-кB activation.
|
29662619 |
2018 |
Carcinogenesis
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
This study is to investigate roles of different UEV1 splicing variants, and its close homolog MMS2, in promoting tumorigenesis and metastasis in breast cancer cells.
|
25022892 |
2014 |
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Our experimental data establish that among NF-κB target genes, UEV1A-regulated matrix metalloproteinase-1 (MMP1) expression plays a critical role in cell invasion and metastasis.
|
25022892 |
2014 |