UCP2, uncoupling protein 2, 7351

N. diseases: 235; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE In UCP2 (G-866A) polymorphism, the distribution of GA (46%) and AA (14%) genotypes were significantly higher in T2D patients than the healthy controls. 30910560 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE For meta-analysis, a literature search was conducted to identify all studies that investigated associations between UCP2 polymorphisms and DKD in patients with T1DM or type 2 diabetes mellitus. 31479096 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE This study suggests that the UCP2 gene may be involved in the pathogenesis of NPDR and PDR in Han Chinese patients with T2D. 30359091 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE The study was to examine the associations of genetic variants of UCP2 and UCP3 with prediabetes and T2DM in a rural Chinese population. 29529994 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Targeting <i>Ucp2</i>/UCP2 as a therapeutic in type 2 diabetes or any other metabolic condition must take into account the rhythmic nature of its expression and its impact on glucose tolerance over 24 h, specifically during the inactive/fasted phase. 28702331 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE The aim of the study was to determine transcriptional levels of UCP1 and UCP2 in peripheral blood mononuclear cells (PBMCs) from patients with metabolic disorders: T2DM, obesity and from healthy individuals. 29151065 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE UCP2 polymorphisms are associated with leukocyte telomere length (LTL) in Type 2 Diabetes, which also induces considerable background oxidative stress. 27615599 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Variants within UCP2 (rs622064; CC vs. A allele carriers OR=1.61; 95% CI: 1.21-2.15, P<0.002) and within TERF2IP (rs8053257; A allele carriers vs. GG, OR=1.78; 95% CI: 1.07-3.18, P<0.03) were associated with increased risk of type 2 diabetes mellitus (T2DM). 26765095 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE In this study, we investigated whether UCP2 -866G/A, Ala55Val and Ins/Del polymorphisms were associated with DKD in patients with type 2 diabetes mellitus (T2DM), and whether they had an effect on UCP2 gene expression in human kidney tissue biopsies. 26218518 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Moreover, the UCP2 rs659366 polymorphism showed no significant difference between DM and control (P = 0.66; OR [95%CI]  = 1.10 (0.91-1.32)). 25396419 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE We found no consistent associations between the UCP2 -866G-allele and obesity or type 2 diabetes. 22349573 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Our 4-year follow-up study shows no association between -866G>A variant of UCP-2 in type 2 diabetes and the risk of developing stroke. 23621569 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Based on our case-control study and meta-analysis, we conclude that UCP2 Ala55Val and -866G/A polymorphisms are not significantly associated with type 2 diabetes risk in the Chinese population. 24065674 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE In our case-control study of people with European ancestry we were not able to demonstrate any association between the UCP polymorphisms and T2DM; however, our meta-analysis detected a significant association between the UCP2 Ala55Val and UCP3 -55C/T polymorphisms and increased susceptibility for T2DM in Asians. 23365654 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Uncoupling protein 2 (UCP2) gene polymorphisms have been reported as genetic risk factors for obesity and type 2 diabetes mellitus (T2DM). 22533685 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE The A allele of the -866G>A variant of UCP2 was associated with increased risk of IS in Chinese diabetic women with type 2 diabetes in a 4-year prospective study. 22613561 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE The authors investigated 23 single nucleotide polymorphisms among 9 genes (ADRB3, ENPP1, FTO, LEP, PPARG, PPARGC1A, SLC2A2, TCF7L2, and UCP2) associated with type 2 diabetes or obesity. 23132673 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE We demonstrated that UCP2-866 G/A polymorphism is associated with the therapeutic efficacy of repaglinide in Chinese T2DM patients. 22393835 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications. 21779625 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE the genotype (P = 0.00006) and the allele (P = 0.00007) frequencies of Ala55Val of the UCP2 gene showed a significant protective effect against the development of type 2 diabetes. 21175267 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Our meta-analysis suggests that the UCP2 -866G/A polymorphism is unlikely to be associated with increased type 2 diabetes risk in the populations investigated. 21751002 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE A total of 930 patients and 867 control subjects were recruited to examine the association between leukocyte telomere length, UCP2 variant (-886G>A), recently identified serological markers, and type 2 diabetes. 21873561 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Mitochondrial uncoupling protein gene cluster variation (UCP2-UCP3) and the risk of incident type 2 diabetes mellitus: the Women's Genome Health Study. 21074158 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Therefore, we studied the association of leukocyte telomere length (LTL) with the presence of T2D, as well as the effect on the patients' LTL of plasma oxidative stress and of variation in UCP2, a gene involved in the mitochondrial production of reactive oxygen species. 19889414 2010
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE To clarify the contribution of the UCP2 gene -866 G/A polymorphism in the Iranian population, we studied its association with obesity and T2D. 20804304 2010