VCAM1, vascular cell adhesion molecule 1, 7412

N. diseases: 406; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.370 AlteredExpression disease BEFREE Vascular function in SCD::Keap1F/F::Tie1-Cre mice was significantly improved, with a 50% decrease in vascular leakage and low expression of the adhesion molecules Vcam1 and P-selectin. 31015205 2019
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.370 AlteredExpression disease BEFREE Markers of endothelial activation (soluble thrombomodulin and soluble vascular cell adhesion molecule-1) and inflammation (tumor necrosis factor-alpha) were both significantly elevated in hemoglobin SC patients when compared to controls, being as high as the levels seen in patients with sickle cell anemia. 25596272 2015
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.370 GeneticVariation disease BEFREE Association of alpha-thalassemia, TNF-alpha (-308G>A) and VCAM-1 (c.1238G>C) gene polymorphisms with cerebrovascular disease in a newborn cohort of 411 children with sickle cell anemia. 25175566 2015
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.370 AlteredExpression disease BEFREE Genetic variation in CD36, HBA, NOS3 and VCAM1 is associated with chronic haemolysis level in sickle cell anaemia: a longitudinal study. 24168396 2014
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.370 GeneticVariation disease BEFREE In whole genome and single gene analyses, genetic variation at the vascular cell adhesion molecule-1 (VCAM-1) locus has been associated with inflammatory disease and stroke in sickle cell anaemia. 24075742 2013
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.370 AlteredExpression disease BEFREE Severe sickle cell anemia is associated with increased plasma levels of TNF-R1 and VCAM-1. 21264913 2011
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.370 Biomarker disease CTD_human Plasma zinc levels inversely correlate with vascular cell adhesion molecule-1 concentration in children with sickle cell disease. 16916123 2006
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.370 GeneticVariation disease BEFREE Variants in the VCAM1 gene and risk for symptomatic stroke in sickle cell disease. 12393616 2002