VEGFA, vascular endothelial growth factor A, 7422

N. diseases: 1899; N. variants: 59
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Vascular endothelial growth factor (VEGF) has been implicated in inflammatory and airway blood vessel remodeling in asthmatics. 31831011 2019
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE The ADAM33 rs528557/S2 and the VEGFA rs833069 SNPs were associated with Thai asthmatics, as well as with other populations worldwide. 31586488 2019
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Increased VEGF serum concentration is characteristic of patients with asthma, especially those with irreversible bronchoconstriction. 30740942 2019
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE The -2549 -2567 del18 Polymorphism in VEGF and Irreversible Bronchoconstriction in Asthmatics. 30574871 2019
CUI: C0004096
Disease: Asthma
Asthma
0.400 AlteredExpression disease BEFREE PDGFBB and VEGF levels were significantly associated with asthma. 31586492 2019
CUI: C0004096
Disease: Asthma
Asthma
0.400 AlteredExpression disease BEFREE EBT is increasing in severe asthma and is significantly modulated by VEGF levels. 29176061 2018
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Importantly, MFG-E8 apparently alleviated OVA-driven airway remodeling, which were evidenced by declined secretion of important mediators of airway remodeling, including transforming growth factor-β1, matrix metalloproteinase 9, ADAM8, and vascular endothelial growth factor, and reduced airway collagen deposition and inhibited goblet cell hyperplasia in OVA-induced asthma in mice. 30076648 2018
CUI: C0004096
Disease: Asthma
Asthma
0.400 AlteredExpression disease BEFREE In addition, there were no correlations between VEGF levels and asthma control test scores. 26996348 2017
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Role of licochalcone A in VEGF-induced proliferation of human airway smooth muscle cells: implications for asthma. 28635361 2017
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Vascular endothelial growth factor (VEGF) has been implicated in inflammatory and airway blood vessel remodeling in asthma. 28056993 2017
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE VEGFA was a hub protein in both the PPI networks of DEGs in notSA vs. NC and SA vs. NC. 27842724 2017
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE We sought to examine the relevance of VEGF gene polymorphisms to asthma in the Chinese Han population. 27173321 2016
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Vascular endothelial growth factor (VEGF) has been implicated in inflammatory and airway blood vessel remodeling in asthmatics. 27579513 2016
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Fatty acid binding protein 4 regulates VEGF-induced airway angiogenesis and inflammation in a transgenic mouse model: implications for asthma. 23391391 2013
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE We studied VEGFA gene variants and plasma levels and the development of lung function, bronchial hyperresponsiveness and asthma in childhood. 24152156 2013
CUI: C0004096
Disease: Asthma
Asthma
0.400 AlteredExpression disease BEFREE It has been shown that treatment of asthma patients decreases VEGF levels, and inhibition of VEGF diminishes asthma symptoms in mice. 22519966 2012
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Abnormal histone methylation is responsible for increased vascular endothelial growth factor 165a secretion from airway smooth muscle cells in asthma. 22689881 2012
CUI: C0004096
Disease: Asthma
Asthma
0.400 AlteredExpression disease BEFREE The levels of HIF-1α and VEGF increased in lung tissue and bronchial fluid of patients with asthma and in the nasal fluid of patients with rhinitis after challenge. 21517900 2011
CUI: C0004096
Disease: Asthma
Asthma
0.400 AlteredExpression disease BEFREE Allergen treatment and lung-specific vascular endothelial growth factor (VEGF) expression induced asthma-like pathologies in the murine lungs. 21595947 2011
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE C. pneumoniae infection of BECs may play a role in the pathogenesis of asthma through the enhanced production of CCL20 and VEGF. 19479364 2009
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease CTD_human Manganese (II) induces chemical hypoxia by inhibiting HIF-prolyl hydroxylase: implication in manganese-induced pulmonary inflammation. 19263519 2009
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE The objective of the present study was to determine whether VEGF single nucleotide polymorphisms (SNPs) are associated with asthma, lung function and airway responsiveness. 19196819 2009
CUI: C0004096
Disease: Asthma
Asthma
0.400 AlteredExpression disease LHGDN Vascular endothelial growth factor overexpression in induced sputum of children with bronchial asthma. 18298425 2009
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Insights into the importance of vascular endothelial growth factor and angiogenesis in asthma pathogenesis now lead to potential new therapeutic possibilities and elucidate why recent advances in asthma therapeutics have been so successful. 18188016 2008
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease LHGDN The aim of this study was to compare vascular endothelial growth factor (VEGF) and its receptor foetal liver kinase (Flk)-1 expression between seasonal AR patients with or without asthma and non-allergic controls as well as that between AR patients with and without asthma. 17651148 2007