Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
VEGFA has been found overexpressed in patients with endometrial cancer, but the VEGFA expression pattern and how it is regulated are still unknown.
|
31587503 |
2020 |
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increased Vascular Endothelial Growth Factor Receptor (VEGF) expression in endometrial cancer (EC) is associated with a poor prognosis.
|
31677820 |
2019 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The expressions of COX-2, p53, and VEGF in endometrial cancer were examined.
|
30488858 |
2019 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our data indicated that simultaneous blockade of VEGF-A and Ang-2 may serve as a novel and effective therapeutic strategy in endometrial cancer.
|
30863089 |
2019 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recent studies have shown that VEGF increases in gynecological diseases (such as endometriosis, ovarian, and endometrial cancers) and is a prognostic factor in these pathologies.
|
31701462 |
2019 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The abnormal high expression of NGAL and VEGF observed in the endometrial carcinoma may be an important biomarker for early tumor diagnosis or as a novel target for therapeutic intervention.
|
29461590 |
2018 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Factors involved in angiogenesis included vascular endothelial growth factor-A (VEGF-A), thrombospondin-1 (TSP-1), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), and aromatase (P450arom), which were increased in endometrial carcinoma.
|
29404887 |
2018 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Collectively, these results provide evidence that VEGF-mTOR signaling drives endometrial cell growth leading to hyperplasia and cancer.<b>Implications:</b> Adipocyte-derived VEGF-mTOR signaling may be an attractive therapeutic target against endometrial cancer in obese women.<i></i>.
|
29133593 |
2018 |
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MAXH28R-expressing EC cells secreted nearly double the levels of VEGFA compared with MAXWT cells (P = .03, .005, and .005 at 24, 48, and 72 hours, respectively), and conditioned media from MAXH28R cells increased sprouting when applied to HUVECs.
|
29155953 |
2018 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
LncRNA TDRG1 enhances tumorigenicity in endometrial carcinoma by binding and targeting VEGF-A protein.
|
29920344 |
2018 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, we demonstrated that treatment with Pro-EGCG not only decreases cancer cell-secreted VEGFA but also inhibits TAM-secreted VEGFA in endometrial cancer.
|
29024813 |
2018 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The study aimed to assess the usefulness of the determination of cytokines: IL-8, VEGF and its soluble receptors: VEGF-R1, VEGF-R2 in patients with endometrial cancer (EC).
|
28991928 |
2017 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
This research will discuss the influence of MMP and VEGF on angiogenesis, metastasis, and the prognosis of EC as well as the clinical importance of the factors in the diagnosis of EC.
|
29033580 |
2017 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Inverse associations with anti-inflammatory markers (IL13, IL21), other inflammation markers/mediators (CCL3, IL1B, IL23), and a robust positive association between VEGFA and endometrial cancer risk were independent of BMI and estradiol, suggesting that these factors may influence risk through other mechanisms.
|
27770434 |
2017 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Bevacizumab, a monoclonal antibody to VEGF, has shown efficacy in ovarian, cervical and endometrial cancer in addition to several other solid tumors.
|
28969913 |
2017 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Alterations of angiogenic factors including angiotensin (AngII) or VEGF are observed in EC.
|
25231075 |
2015 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We assessed the safety and activity of dovitinib, a potent tyrosine-kinase inhibitor of fibroblast growth factor receptors, VEGF receptors, PDGFR-β, and c-KIT, as second-line therapy both in patients with FGFR2-mutated (FGFR2(mut)) endometrial cancer and in those with FGFR2-non-mutated (FGFR2(non-mut)) endometrial cancer.
|
25981814 |
2015 |
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemically, 63% of endometrial cancers expressed VEGF-A, 55% VEGFR2 and 26% VEGFR3.
|
24845798 |
2014 |
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We aimed to investigate whether VEGF and TGFB1 serve as markers of the malignant transformation of the endometrium and whether VEGF or TGFB1 expression can constitute a useful prognostic marker of survival in patients with endometrial carcinoma.
|
23176363 |
2013 |
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this study we compared the expression of MIF mRNA with VEGF mRNA expression and with mRNA expression of other chemokines related to neo-angiogenesis, such as CXCL12, CXCL11, CXCL8 and CXCR4, in human endometrial cancer tissue (EC) and normal endometrium (NE).
|
23985752 |
2013 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adrenomedullin interacts with VEGF in endometrial cancer and has varied modulation in tumours of different grades.
|
22178239 |
2012 |
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Further studies are required to clarify the biological function of the angiotensin receptor in regulating VEGF expression in endometrial carcinoma.
|
22170435 |
2012 |
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A dysregulated expression of miRNAs related to angiogenesis and an increase in the VEGF-A levels were observed in endometrial cancer in comparison with control.
|
22904162 |
2012 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Insulin-like growth factors (IGFs), vascular endothelial growth factor (VEGF), hypoxia-inducible factor-1 (HIF-1), and nuclear factor kappa-B (NF-κB) are known to play an important role in endometrial cancer pathogenesis.
|
22711307 |
2012 |
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Biologically inhibitory effects of VEGF siRNA on endometrial carcinoma cells.
|
22057922 |
2011 |