VEGFA, vascular endothelial growth factor A, 7422

N. diseases: 1899; N. variants: 59
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 Biomarker disease BEFREE The aim of this study was to determine whether VEGF/VEGFRs could be used as prognostic biomarkers in patients with CC. 31236742 2019
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 AlteredExpression disease BEFREE Formononetin can inhibit the growth of cervical cancer and reduce the mRNA and protein expression levels of HIF-1α and VEGF in mouse cervical cancer. 31452725 2019
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 AlteredExpression disease BEFREE We compared the plasma levels of M-CSF and VEGF to the ones of commonly accepted tumor markers CA 125and SCC-Ag in three groups of patients: 1. the cervical cancer group (patients with either squamous cell carcinoma or adenocarcinoma); 2. the cervical dysplasia group; 3. the control group. 31035945 2019
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 AlteredExpression disease BEFREE Moreover, data revealed positive correlation between plasma level and cervical cancer cell expression of VEGF. 31704874 2019
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 AlteredExpression disease BEFREE Our study demonstrated that PSMA7 silencing can suppress CC cell proliferation and VEGF expression in addition to promoting cell apoptosis through inhibiting the UPP signaling pathway. 29247526 2019
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 Biomarker disease BEFREE In the total CC, stage I, and stage II groups, all tested parameters showed statistically significant area under the receiver operating characteristics curve (AUC), but maximum range was obtained for the combination VEGF + SCC-Ag (I: 0.9146, II: 0.8941, III + IV: 0.9139, total CC group: 0.9347). 30037277 2018
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 Biomarker disease BEFREE Vascular endothelial growth factor (VEGF) has emerged as a therapeutic target in several malignancies, including cervical cancer. 29666026 2018
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 AlteredExpression disease BEFREE VEGF expression is significantly positively correlated with miR-21 expression, and the high levels of VEGF and miR-21 predict unfavorable prognosis of cervical cancer. 30338794 2018
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 Biomarker disease BEFREE CD31 and vascular endothelial growth factor (VEGF) were stained to reflect tumor angiogenesis in 67 CC tissues. 30458457 2018
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 Biomarker disease BEFREE Deregulation of LIMD1-VHL-HIF-1α-VEGF pathway is associated with different stages of cervical cancer. 29654110 2018
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 AlteredExpression disease BEFREE A significantly higher expression of VEGF was identified in post-radiotherapy relapsed/persistent cervical cancer compared with typical specimens from cervical cancer. 29928441 2018
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 Biomarker disease BEFREE The results of the present study suggested that TSLP derived of cervical cancer cells may indirectly stimulate angiogenesis of HUVECs, by upregulating IL-8 and VEGF production, in a co-culture model between cervical cancer cells and EOS, therefore promoting the development of cervical cancer. 29344192 2017
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 Biomarker disease BEFREE Although anti-vascular endothelial growth factor drugs have shown great promise as a therapeutic target for treatment of advanced cervical cancer, drug resistance and class-specific side effects negate long-term benefits. 28720059 2017
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 Biomarker disease BEFREE Prognostic role of vascular endothelial growth factor in cervical cancer: a meta-analysis. 28177889 2017
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 Biomarker disease BEFREE The present study investigated the clinicopathological significance of the coexpression of LAPTM4B-35 and VEGF in patients with cervical cancer. 26526574 2016
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 AlteredExpression disease BEFREE Data have shown that VEGF expression levels are associated with hTERT expressions and telomerase activity in HPV-positive cervical cancer tissues and cells. 26067630 2015
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 AlteredExpression disease BEFREE To investigate the effect of recombinant human p53 adenovirus injection combined with paclitaxel on human cervical cancer HeLa cell proliferation, apoptosis and expression of vascular endothelial growth factor (VEGF). 25855930 2015
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 Biomarker disease CTD_human PIAS3, SHP2 and SOCS3 Expression patterns in Cervical Cancers: Relevance with activation and resveratrol-caused inactivation of STAT3 signaling. 26432044 2015
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 GeneticVariation disease BEFREE Specific VEGF variants (rs699947, rs1570360) and haplotype (CTGCCAG) may contribute to the development of CC among Tunisian women. 25541433 2015
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 Biomarker disease BEFREE Effects of VEGF suppression by small hairpin RNA interference combined with radiotherapy on the growth of cervical cancer. 25061734 2014
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 AlteredExpression disease BEFREE The mRNA expression level of TLR8 in the patients with cervical cancer and Hela cells were up-regulated, it consistent with the increased expression of VEGF and Bcl-2. 24782650 2014
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 AlteredExpression disease BEFREE Function of inducible nitric oxide synthase in the regulation of cervical cancer cell proliferation and the expression of vascular endothelial growth factor. 24297386 2014
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 Biomarker disease BEFREE To figure out the involved signaling pathways, we applied specific inhibitors for ERK/MAPK, JNK, and PI3K/Akt signaling pathways, respectively, to VEGFa-overexpressing cervical cancer lines and found that only inhibition of PI3K/Akt signal transduction abolished VEGFa-induced increases in cell growth and invasiveness. 25135429 2014
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 Biomarker disease BEFREE Our findings have demonstrated that the miR-196b/HOXB7/VEGF pathway plays an important role in cervical cancer progression; hence targeting this pathway could be a promising therapeutic strategy for the future management of this disease. 23861821 2013
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 AlteredExpression disease BEFREE To detect vascular endothelial growth factor (VEGF)-C mRNA expression in surgically resected tissues of 'pathologic N0' (pN0) cervical cancer; to investigate the relevance of VEGF-C mRNA expression to clinicopathological factors, lymph node recurrence and prognosis in early stage cervical cancer. 23963849 2013