VHL, von Hippel-Lindau tumor suppressor, 7428

N. diseases: 372; N. variants: 215
Disease: Adenoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001430
Disease: Adenoma
Adenoma 		0.350 Biomarker group CTD_human Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency. 16061637 2005
CUI: C0001430
Disease: Adenoma
Adenoma 		0.350 GeneticVariation group BEFREE No adenoma showed LOH of the vHL gene markers studied. 9744312 1998
CUI: C0001430
Disease: Adenoma
Adenoma 		0.350 GeneticVariation group BEFREE Results of an analysis of sporadic patients with multiple renal tumours indicate an association of allelic losses of the VHL and 3p12-p14 regions with adenomas and suggest that losses of the 3p21 region are necessary for malignant development to clear cell or nonpapillary RCC. 9171996 1997
CUI: C0001430
Disease: Adenoma
Adenoma 		0.350 GeneticVariation group BEFREE However, genetic alterations of the VHL gene in MCAs of the pancreas have never been reported. 9327728 1997
CUI: C0001430
Disease: Adenoma
Adenoma 		0.350 GeneticVariation group BEFREE Irrespective of showing loss or retention of the 3p25 region, none of the adenomas had a VHL mutation. 9258657 1997
CUI: C0001430
Disease: Adenoma
Adenoma 		0.350 GeneticVariation group BEFREE The authors have analyzed VHL gene alterations on chromosome 3p in sporadic human colon carcinomas and adenomas using modified microdissection techniques. 8617456 1996