WT1, WT1 transcription factor, 7490

N. diseases: 446; N. variants: 61
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Leukemic cells from seventy patients with various types of human leukemias were examined for expression of the WT1 gene, the Wilms' tumor gene located at chromosome 11p13. 1317488 1992
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Significant levels of WT1 gene were expressed in all leukemia patients and for CML the levels increased as the clinical phase progressed. 7949179 1994
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation disease BEFREE The Wilms tumour (WT1) gene is mutated in a secondary leukaemia in a WAGR patient. 7833922 1994
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Using the anti-WT1 MoAb 6F-H2 in an immunofluorescence assay on single cell level, we found the translated WT1 protein only in nuclei of leukemia blast cells but not in nuclei of normal CD34+ hematopoietic progenitor cells. 7596170 1995
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation disease BEFREE Mutation analysis of the WT1 gene in sporadic childhood leukaemia. 9001425 1997
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE The expression of the WT-1 gene which is found exclusively in human leukemic blasts frequently disappears from bone marrow of leukemia patients in complete remission (CR). 9339129 1997
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Minimal residual disease (MRD) of leukemia can be detected at frequencies as low as 1 in 10(3) to 10(4) normal bone marrow (BM) cells and 1 in 10(5) normal peripheral blood (PB) cells by means of the quantitation of expression levels of the WT1 gene using reverse transcriptase-polymerase chain reaction (RT-PCR). 9669676 1998
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE In vitro IL-12 treatment of peripheral blood mononuclear cells from patients with leukemia or myelodysplastic syndromes: increase in cytotoxicity and reduction in WT1 gene expression. 10995011 2000
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE This finding suggests strongly that WT1 protein is a potential target of immunotherapy for human leukemia. 10607714 2000
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE However, the wild-type WT1 gene is highly expressed in leukemic blast cells of myeloid and lymphoid origin, and thus, WT1 messenger RNA provides a novel tumor marker for detection of minimal residual disease of leukemias and for monitoring disease progression of myelodysplastic syndromes. 11372729 2001
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE The usefulness of monitoring WT1 gene transcripts for the prediction and management of relapse following allogeneic stem cell transplantation in acute type leukemia. 12406915 2003
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease LHGDN Multiplex real-time RT-PCR for prospective evaluation of WT1 and fusion gene transcripts in newly diagnosed de novo acute myeloid leukemia. 15223639 2004
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease CTD_human WT1 is a tumor-associated antigen in colon cancer that can be recognized by in vitro stimulated cytotoxic T cells. 14961577 2004
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease LHGDN Use of B cell-bound HLA-A2 class I monomers to generate high-avidity, allo-restricted CTLs against the leukemia-associated protein Wilms tumor antigen. 14988155 2004
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE The extent of minimal residual disease (MRD) of leukemia can be evaluated by measuring the WT1 gene expression level using a quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) method. 15223632 2004
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation disease BEFREE To explore the possibility of gene therapy for leukemia using WT1 promoter and enhancer, their activities in several kinds of cells were analyzed by using the enhanced green fluorescent protein (EGFP) gene as a reporter. 14737070 2004
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease LHGDN Direct recognition and lysis of leukemia cells by WT1-specific CD4+ T lymphocytes in an HLA class II-restricted manner. 15845894 2005
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE These results showed that Th1-biased humoral immune responses against WT1 protein were generated in leukemias and MDS. 15538407 2005
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Wilms tumor protein 1 (WT1) is a transcription factor overexpressed in several types of leukemia and solid tumors. 16990779 2006
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Taken together, these results demonstrate that A1 is a new WT1 target gene involved in both granulocytic differentiation and resistance to cell death, and suggests that these genes might play an important role in the biology of high-risk leukemias. 16484585 2006
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Leukemias are common worldwide.Wilms' tumor1 (WT1) protein is highly expressed in leukemic blast cells of myeloid and lymphoid origin. 16491848 2006
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation disease BEFREE Recently, oncogenic potential of the WT1 gene has been proposed in some human solid tumors and leukemias. 17594113 2007
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease LHGDN Quantitative assessment of WT1 expression in diagnosis of childhood acute leukemia. 16876863 2007
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE The Wilms' tumour gene 1 (WT1) protein is highly expressed in most leukaemias. 17728783 2007
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation disease BEFREE Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. 18559874 2008