leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Leukemic cells from seventy patients with various types of human leukemias were examined for expression of the WT1 gene, the Wilms' tumor gene located at chromosome 11p13.
|
1317488 |
1992 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Significant levels of WT1 gene were expressed in all leukemia patients and for CML the levels increased as the clinical phase progressed.
|
7949179 |
1994 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Wilms tumour (WT1) gene is mutated in a secondary leukaemia in a WAGR patient.
|
7833922 |
1994 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using the anti-WT1 MoAb 6F-H2 in an immunofluorescence assay on single cell level, we found the translated WT1 protein only in nuclei of leukemia blast cells but not in nuclei of normal CD34+ hematopoietic progenitor cells.
|
7596170 |
1995 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutation analysis of the WT1 gene in sporadic childhood leukaemia.
|
9001425 |
1997 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The expression of the WT-1 gene which is found exclusively in human leukemic blasts frequently disappears from bone marrow of leukemia patients in complete remission (CR).
|
9339129 |
1997 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Minimal residual disease (MRD) of leukemia can be detected at frequencies as low as 1 in 10(3) to 10(4) normal bone marrow (BM) cells and 1 in 10(5) normal peripheral blood (PB) cells by means of the quantitation of expression levels of the WT1 gene using reverse transcriptase-polymerase chain reaction (RT-PCR).
|
9669676 |
1998 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In vitro IL-12 treatment of peripheral blood mononuclear cells from patients with leukemia or myelodysplastic syndromes: increase in cytotoxicity and reduction in WT1 gene expression.
|
10995011 |
2000 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This finding suggests strongly that WT1 protein is a potential target of immunotherapy for human leukemia.
|
10607714 |
2000 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
However, the wild-type WT1 gene is highly expressed in leukemic blast cells of myeloid and lymphoid origin, and thus, WT1 messenger RNA provides a novel tumor marker for detection of minimal residual disease of leukemias and for monitoring disease progression of myelodysplastic syndromes.
|
11372729 |
2001 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The usefulness of monitoring WT1 gene transcripts for the prediction and management of relapse following allogeneic stem cell transplantation in acute type leukemia.
|
12406915 |
2003 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Multiplex real-time RT-PCR for prospective evaluation of WT1 and fusion gene transcripts in newly diagnosed de novo acute myeloid leukemia.
|
15223639 |
2004 |
leukemia
|
0.400 |
Biomarker
|
disease |
CTD_human |
WT1 is a tumor-associated antigen in colon cancer that can be recognized by in vitro stimulated cytotoxic T cells.
|
14961577 |
2004 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Use of B cell-bound HLA-A2 class I monomers to generate high-avidity, allo-restricted CTLs against the leukemia-associated protein Wilms tumor antigen.
|
14988155 |
2004 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The extent of minimal residual disease (MRD) of leukemia can be evaluated by measuring the WT1 gene expression level using a quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) method.
|
15223632 |
2004 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To explore the possibility of gene therapy for leukemia using WT1 promoter and enhancer, their activities in several kinds of cells were analyzed by using the enhanced green fluorescent protein (EGFP) gene as a reporter.
|
14737070 |
2004 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Direct recognition and lysis of leukemia cells by WT1-specific CD4+ T lymphocytes in an HLA class II-restricted manner.
|
15845894 |
2005 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results showed that Th1-biased humoral immune responses against WT1 protein were generated in leukemias and MDS.
|
15538407 |
2005 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Wilms tumor protein 1 (WT1) is a transcription factor overexpressed in several types of leukemia and solid tumors.
|
16990779 |
2006 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, these results demonstrate that A1 is a new WT1 target gene involved in both granulocytic differentiation and resistance to cell death, and suggests that these genes might play an important role in the biology of high-risk leukemias.
|
16484585 |
2006 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Leukemias are common worldwide.Wilms' tumor1 (WT1) protein is highly expressed in leukemic blast cells of myeloid and lymphoid origin.
|
16491848 |
2006 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, oncogenic potential of the WT1 gene has been proposed in some human solid tumors and leukemias.
|
17594113 |
2007 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Quantitative assessment of WT1 expression in diagnosis of childhood acute leukemia.
|
16876863 |
2007 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The Wilms' tumour gene 1 (WT1) protein is highly expressed in most leukaemias.
|
17728783 |
2007 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study.
|
18559874 |
2008 |