Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Downregulation of the WT1 gene expression via TMPyP4 stabilization of promoter G-quadruplexes in leukemia cells. 26815508 2017
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Of these, 230 were monitored concurrently for minimal residual disease (MRD) by flow cytometry (FCM) for leukemia-associated aberrant immune phenotypes and by RQ-PCR for the expression of the Wilms tumor (WT1) gene. 24631740 2015
CUI: C0023418
Disease: leukemia
leukemia
0.400 PosttranslationalModification disease BEFREE We describe a methylation signature of the AWT1 promoter CpG island that is a promising marker for classifying myeloid-derived leukemias. 24405639 2014
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE The expression of WT1 gene was measured according to the European Leukaemia Net recommendations. 23231003 2013
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation disease BEFREE Clinical outcome and gene- and microRNA-expression profiling according to the Wilms tumor 1 (WT1) single nucleotide polymorphism rs16754 in adult de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. 21659357 2012
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Wilms' tumor (WT1) protein is one of the potent tumor antigens inducing immunological response in mouse and human, because WT1 is over expressed in many types of leukemia and various kinds of solid tumors. 21963635 2012
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Most cases of leukemia show hTERT and WT1 gene overexpression. 21314483 2011
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE The WT1 gene is highly expressed in leukemia and various types of solid tumors, whereas WT1 is a tumor marker convenient for the detection of minimal residual disease of leukemia. 20395243 2010
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Graft-versus-leukemia effects of Wilms' tumor 1 protein-specific cytotoxic T lymphocytes in patients with chronic myeloid leukemia after allogeneic hematopoietic stem cell transplantation. 20497687 2010
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation disease BEFREE Mutations of the Wilms tumor 1 gene (WT1) in older patients with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. 20442368 2010
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE The Wilms' tumor 1 (WT1) gene is overexpressed in leukemia and various types of solid tumor, such as lung and colorectal cancer, and plays an oncogenic role in their tumorigenesis. 20180815 2010
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE WT1 gene expression has been proposed as a useful marker of minimal residual disease in leukaemia. 19650884 2010
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE This review examines evidence from preclinical experiments and initial clinical trials to critically assess both the potential and current limitations of adoptive transfer of donor T-cells sensitized to selected minor alloantigens of the host or to peptide epitopes of proteins, differentially expressed by clonogenic leukemia cells, such as the Wilms tumor protein, WT-1, as a strategy to treat or prevent recurrence of leukemia in the post-transplant period. 20537908 2010
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE In addition, vaccination of C57BL/6 mice with Ad-tWT1 generated WT1-specific cell-mediated and humoral immune responses and conferred protection against challenge with the leukemia cell line, mWT1-C1498. 19351755 2009
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE The WT1 protein has been found to be highly immunogenic, and spontaneous humoral and cytotoxic T-cell responses have been detected in patients suffering from leukemia. 19357702 2009
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation disease BEFREE Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. 18559874 2008
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation disease BEFREE Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: the United Kingdom Medical Research Council Adult Leukaemia Working Party. 18591546 2008
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation disease BEFREE Recently, oncogenic potential of the WT1 gene has been proposed in some human solid tumors and leukemias. 17594113 2007
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Graft-versus-leukemia effects associated with detectable Wilms tumor-1 specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemia. 17505014 2007
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease LHGDN High levels of WT1 expression is associated with childhood acute leukemia 16876863 2007
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE The Wilms' tumour gene 1 (WT1) protein is highly expressed in most leukaemias. 17728783 2007
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Wilms tumor protein 1 (WT1) is a transcription factor overexpressed in several types of leukemia and solid tumors. 16990779 2006
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Taken together, these results demonstrate that A1 is a new WT1 target gene involved in both granulocytic differentiation and resistance to cell death, and suggests that these genes might play an important role in the biology of high-risk leukemias. 16484585 2006
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE N-terminally truncated WT1 protein with oncogenic properties overexpressed in leukemia. 16698800 2006
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Leukemias are common worldwide.Wilms' tumor1 (WT1) protein is highly expressed in leukemic blast cells of myeloid and lymphoid origin. 16491848 2006