XBP1, X-box binding protein 1, 7494

N. diseases: 234; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma
0.330 Biomarker disease BEFREE More importantly, xanthatin treatment markedly increased the expression levels of the endoplasmic reticulum (ER) stress-related markers in both the glioma cell lines as well as in C6 xenografts, including glucose-regulated protein 78, C/EBP-homologous protein (CHOP), activating factor 4, activating transcription factor 6, spliced X-box binding protein-1, phosphorylated protein kinase R-like endoplasmic reticulum kinase, and phosphorylated eukaryotic initiation factor 2a. 31700088 2020
CUI: C0017638
Disease: Glioma
Glioma
0.330 Biomarker disease BEFREE Our results revealed that XBP1s activation was involved in glioma glycolysis regulation and might be a potential molecular target for glioma treatment. 26680227 2016
CUI: C0017638
Disease: Glioma
Glioma
0.330 Biomarker disease CTD_human XBP1 confers an important role in protection against oxidative stress in gliomas, potentially via up-regulation of antioxidant molecules such as catalase. 21138464 2011
CUI: C0017638
Disease: Glioma
Glioma
0.330 AlteredExpression disease BEFREE Expression of XBP1 and antioxidant molecules was also detected in surgically excised specimens from 30 patients with glioma, and 10 normal brain control specimens obtained at autopsy. 21138464 2011