XBP1, X-box binding protein 1, 7494

N. diseases: 234; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker disease BEFREE We used a murine model of MM with transgenic overexpression of the unfolded protein response sensor X-box binding protein 1 (XBP1s) in the B cell compartment to define MM stem cells. 30944260 2019
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 GeneticVariation disease BEFREE MM cells may co-opt the IRE1α-XBP1s pathway; however, the validity of IRE1α as a potential MM therapeutic target is controversial. 31371506 2019
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker disease BEFREE The identified immunogenic HLA-A24-specific XBP1 unspliced (UN)<sub>185-193</sub> (I S P W I L A V L), XBP1 spliced (SP)<sub>223-231</sub> (V Y P E G P S S L), CD138<sub>265-273</sub> (I F A V C L V G F) and CS1<sub>240-248</sub> (L F V L G L F L W) peptides induced antigen-specific CTL with anti-MM activity in an HLA-A24 restricted manner. 29089645 2018
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker disease BEFREE The endoplasmic reticulum kinase inositol-requiring enzyme 1 (IRE1) and its downstream target X-box-binding protein 1 (XBP1) drive B-cell differentiation toward plasma cells and have been shown to contribute to multiple myeloma development; yet, little is known of the role of this pathway in diffuse large B-cell lymphoma (DLBCL). 28167662 2017
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 AlteredExpression disease BEFREE The expression level of Xbp-1s was measured in 4 MM cell lines and correlated with sensitivity to bortezomib. 27647225 2017
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker disease BEFREE Our study not only confirmed the utilization of topological data analysis in drug discovery but also identified a class of compounds with a unique mechanism of action as potent IRE1α-XBP1 inhibitors in the treatment of multiple myeloma. 27307600 2016
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker disease BEFREE Moreover, siRNA knockdown of XBP-1 disrupted TM- or DTT-induced myeloma cell differentiation and maturation. 24356728 2015
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker disease BEFREE Finally, SCH727965 diminished myeloma cell growth in vivo in association with XBP-1s downregulation. 24362465 2014
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker disease BEFREE These data indicate that targeting XBP-1 has potential as a treatment strategy, not only for multiple myeloma, but also for mature B cell leukemia and lymphoma. 24812669 2014
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 GeneticVariation disease BEFREE Genetic deletion of gp96 in XBP1s-Tg mice attenuates multiple myeloma. 24077352 2013
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker disease BEFREE Taken together, our results demonstrate that blockade of XBP1 splicing by inhibition of IRE1α endoribonuclease domain is a potential therapeutic option in MM. 22538852 2012
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker disease BEFREE Our results demonstrate that XBP1s is a pathogenic factor underlying BMSC support of MM cell growth and osteoclast formation and therefore represents a therapeutic target for MM bone disease. 22427205 2012
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 AlteredExpression disease BEFREE Expression of XBP-1 and other regulators of the unfolded protein response were measured in myeloma and other cancer cell lines and two cohorts of patients with refractory myeloma and correlated with sensitivity/response to bortezomib. 21993678 2012
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker disease BEFREE We have determined the gene expression levels of IRE1alpha, XBP1, XBP1UNSPLICED (XBP1u), and XBP1SPLICED (XBP1s) in a series of patients with myeloma and correlated findings with clinical outcome. 20421453 2010
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker disease BEFREE None of the low-grade lymphomas showed evidence of Xbp-1 activation; however, Xbp-1 activation was found in 28% of diffuse large B-cell lymphomas, independent of germinal or postgerminal center phenotype, as well as in 48% of plasmablastic lymphomas and 69% of plasma-cell neoplasms. 19389935 2009
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker disease BEFREE Blimp-1 ASODN and Xbp-1 ASODN clearly inhibited myeloma cell differentiation and significantly partially inhibited the differentiation effects induced by 2ME2 at low concentration, whereas PAX-5 ASODN clearly induced myeloma cell differentiation and significantly enhanced 2ME2-induced differentiation effects. 18192112 2007
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker disease BEFREE The similarities of this model with the human disease, coupled with documented frequent XBP-1s overexpression in human MM, serve to implicate XBP-1s dysregulation in MM pathogenesis. 17418411 2007
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 AlteredExpression disease BEFREE Coordination of upregulated XBP-1 and downregulated c-myc during myeloma cell differentiation induced by 2-methoxyestradiol. 17257674 2007
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 AlteredExpression disease LHGDN The similarities of this model with the human disease, coupled with documented frequent XBP-1s overexpression in human MM, serve to implicate XBP-1s dysregulation in MM pathogenesis. 17418411 2007
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 GeneticVariation disease BEFREE Analysis of XBP-1, a transcriptional inducer of chaperones, in freshly isolated MMCs from 22 myeloma cases revealed 10 cases with active XBP-1, who also showed significantly poorer survival (p < 0.05), suggesting that chaperone expression protects MMCs from apoptosis, thereby allowing tumor cell expansion. 16396777 2006
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 AlteredExpression disease BEFREE Targeting positive regulatory domain I-binding factor 1 and X box-binding protein 1 transcription factors by multiple myeloma-reactive CTL. 16002735 2005
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 AlteredExpression disease BEFREE XBP-1 transcripts are found at high levels in plasma cells from rheumatoid synovium and myeloma cell lines. 12846805 2003
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker disease BEFREE These results indicate that MBP-1 and XBP-1 are IL-6 genes in myeloma cells; as such, they may play a role in IL-6-mediated growth control in multiple myeloma. 10375612 1999